2. Gene
  3. NAA20 - N-alpha-acetyltransferase 20, NatB catalytic subunit Gene

NAA20 - N-alpha-acetyltransferase 20, NatB catalytic subunit Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：N-α-乙酰转移酶 20，NatB 催化亚基

种属: Homo sapiens

同用名: NAT3; NAT5; MRT73; NAT3P; NAT5P; dJ1002M8.1

基因 ID: 51126 | 基因类型: protein coding

关于 NAA20

Cytogenetic location: 20p11.23 Genomic coordinates (GRCh38): 20:20,017,290-20,033,655 (from NCBI)

This gene has 7 transcripts (splice variants), 214 orthologues, 4 paralogues and is associated with 3 phenotypes. Ubiquitous expression in esophagus (RPKM 49.8), testis (RPKM 35.7) and 25 other tissues.

功能概要

NAT5 是 N-乙酰转移酶复合物 B (NatB) 的一个组成部分。人 NatB 在天冬酰胺后进行甲硫氨酸残基的共翻译 N (alpha) -末端乙酰化 (Starheim 等人，2008 [PubMed 18570629]) 。[OMIM 提供，2009 年 4 月]

NAT5 is a component of N-acetyltransferase complex B (NatB). Human NatB performs cotranslational N(alpha)-terminal acetylation of methionine residues when they are followed by asparagine (Starheim et al., 2008 [PubMed 18570629]).[supplied by OMIM, Apr 2009]

NAA20 基因产物(3)

mRNA Protein Name
NM_016100.5 NP_057184.1 N-alpha-acetyltransferase 20 isoform a
NM_181527.3 NP_852668.1 N-alpha-acetyltransferase 20 isoform b
NM_181528.3 NP_852669.1 N-alpha-acetyltransferase 20 isoform c
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18570629 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in N-terminal peptidyl-aspartic acid acetylation IDA
IDA: 通过直接分析推断
34230638 GOA
involved in N-terminal peptidyl-glutamic acid acetylation IDA
IDA: 通过直接分析推断
34230638 GOA
involved in N-terminal peptidyl-glutamine acetylation IDA
IDA: 通过直接分析推断
34230638 GOA
involved in N-terminal protein amino acid acetylation IDA
IDA: 通过直接分析推断
34230638 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of NatB complex IPI
IPI: 通过物理相互作用推断
18570629 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
18570629 GOA
located in nucleus IDA
IDA: 通过直接分析推断
25732826 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NAA20 蛋白结构

Acetyltransf_1

Acetyltransf_1: Acetyltransferase (GNAT) family (50 - 128)

  • 0
  • 100
  • 178 a.a.
蛋白主名 其他名称

N-alpha-acetyltransferase 20

N-acetyltransferase 3 homolog

NAA20 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NAA20 P61599 NAA25 Homo sapiens Q14CX7
Anti Bait CoIP
18570629
种属内
NAA20 P61599 NAA25 Homo sapiens Q14CX7
Anti Tag CoIP
18570629
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Intellectual Developmental Disorder, Autosomal Recessive 73

MRT73

Autosomal Recessive Intellectual Developmental Disorder 73
Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid
Microphthalmia, Syndromic 1

MCOPS1

Lenz Microphthalmia Syndrome

Lenz Dysplasia

Mcops4

Syndromic Microphthalmia 1

Lenz Microphthalmia

Maa

Microphthalmia Or Anophthalmos With Associated Anomalies

Syndromic Microphthalmia Type 4

Microphthalmia, Syndromic 4

Microphthalmia, Syndromic 4, Formerly

Mcops4, Formerly

Anop1, Formerly

Maa, Formerly

Lenz Type Microphthalmia

Syndromic Microphthalmia 4

Microphthalmia Lenz Type

Microphthalmia Syndromic 1

Syndromic Microphthalmia Type 1

Microphthalmia Syndromic 4

Microphthalmia With Ankyloblepharon And Intellectual Disability

Microphthalmia, Lenz Type

Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome

Microphthalmia, Syndromic, 1

Anop1

Microphthalmia, Syndromic, Type 1
Syndromic Microphthalmia

Microphthalmia, Syndromic
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08988 NAA20 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus NAA20 VGNC VGNC:82879
Rattus norvegicus NAA20 RGD RGD:1307713
Macaca mulatta NAA20 VGNC VGNC:84533
Canis familiaris NAA20 VGNC VGNC:54751
Bos taurus NAA20 VGNC VGNC:57011
Mus musculus NAA20 MGD MGI:1915127
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