1. Gene
  2. SSH3 - slingshot protein phosphatase 3 Gene

SSH3 - slingshot protein phosphatase 3 Gene

中文名称:弹弓蛋白磷酸酶 3

种属: Homo sapiens

同用名: SSH3L

基因 ID: 54961 | 基因类型: protein coding

关于 SSH3

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,303,530-67,312,592 (from NCBI)

This gene has 11 transcripts (splice variants), 193 orthologues and 30 paralogues. Ubiquitous expression in urinary bladder (RPKM 17.7), prostate (RPKM 14.2) and 25 other tissues.

功能概要

ADF (肌动蛋白解聚因子) /cofilin 家族 (参见 MIM 601442) 由肌动蛋白动力学的刺激响应介质组成。 ADF/肌动蛋白丝切蛋白被 LIM 结构域激酶-1 (LIMK1; MIM 601329) 等激酶灭活。 SSH 家族似乎通过在体内重新激活 ADF/cofilin 蛋白在肌动蛋白动力学中发挥作用 (Niwa 等人,2002 [PubMed 11832213]) 。[OMIM 提供,2008 年 3 月]

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]

SSH3 基因产物(1)

mRNA Protein Name
NM_017857.4 NP_060327.3 protein phosphatase Slingshot homolog 3
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SSH3 蛋白结构

DEK_C

DEK_C: DEK C terminal domain (272 - 320)

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (336 - 464)

  • 0
  • 200
  • 400
  • 600
  • 659 a.a.
蛋白主名 其他名称

protein phosphatase Slingshot homolog 3

SSH-3L

关联疾病

疾病名称 别名
Epilepsy, Idiopathic Generalized 17

Febrile Seizures, Familial, 2

EIG17

Familial Febrile Seizures 2

FEB2

Epilepsy, Idiopathic Generalized, Susceptibility To, 17

Familial Febrile Convulsions 2

Convulsions, Familial Febrile, 2

Endosteal Hyperostosis, Autosomal Dominant

Osteosclerosis

Worth Syndrome

Osteosclerosis, Autosomal Dominant

Hyperostosis, Endosteal

Endosteal Hyperostosis, Worth Type

Worth Disease

Autosomal Dominant Endosteal Hyperostosis

Autosomal Dominant Osteosclerosis, Worth Type

Hyperostosis Corticalis Generalisata, Benign Form Of Worth, With Torus Palatinus

Autosomal Dominant Osteosclerosis

Benign Form Of Worth Hyperostosis Corticalis Generalisata With Torus Platinus

Worth'S Syndrome

Worth Type Autosomal Dominant Osteosclerosis

Hyperostosis Corticalis Generalisata, Benign Form Of Worth With Torus Palatinus

Osteosclerosis, Autosomal Dominant, Worth Type

WENHY

Endosteal Hyperostosis Autosomal Dominant

Hyperostosis Corticalis Generalisata Benign Form Of Worth With Torus Palatinus

Osteosclerosis Autosomal Dominant

Acquired Osteosclerosis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SSH3 RGD RGD:1308679
Felis catus SSH3 VGNC VGNC:65705
Canis familiaris SSH3 VGNC VGNC:46833
Macaca mulatta SSH3 VGNC VGNC:78019
Mus musculus SSH3 MGD MGI:2683546
Bos taurus SSH3 VGNC VGNC:35314