H2AJ - H2A.J histone Gene

中文名称：H2A.J 组蛋白

种属: Homo sapiens

同用名: H2AFJ

关于 H2AJ

功能概要

组蛋白是基本的核蛋白，负责真核生物染色体纤维的核小体结构。核小体由大约 146 bp 的 DNA 组成，包裹在由四种核心组蛋白 (H2A、H2B、H3 和 H4) 中的每一种成对组成的组蛋白八聚体周围。染色质纤维通过接头组蛋白 H1 与核小体之间的 DNA 相互作用进一步压缩，形成更高阶的染色质结构。该基因位于 12 号染色体上，编码一种不依赖于复制的组蛋白，该组蛋白是一种变体 H2A 组蛋白。与共有的 H2A 组蛋白家族成员相比，该蛋白质在 C 末端有所不同。该基因还编码具有抗菌和抗真菌活性的抗菌肽。[RefSeq 提供，2015 年 10 月]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is located on chromosome 12 and encodes a replication-independent histone that is a variant H2A histone. The protein is divergent at the C-terminus compared to the consensus H2A histone family member. This gene also encodes an antimicrobial peptide with Antibacterial and Antifungal activity.[provided by RefSeq, Oct 2015]