2. Gene
  3. MINDY1 - MINDY lysine 48 deubiquitinase 1 Gene

MINDY1 - MINDY lysine 48 deubiquitinase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MINDY 赖氨酸 48 去泛素化酶 1

种属: Homo sapiens

同用名: FAM63A; MINDY-1

基因 ID: 55793 | 基因类型: protein coding

关于 MINDY1

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:150,996,536-151,008,393 (from NCBI)

This gene has 7 transcripts (splice variants), 207 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 17.7), testis (RPKM 8.4) and 25 other tissues.

功能概要

启用 K48 连接的多聚泛素修饰依赖性蛋白质结合活性； Lys48 特异性去泛素化酶活性；和半胱氨酸型羧肽酶活性。预计参与蛋白质 K48 连接的去泛素化。位于核体。 [由基因组资源联盟提供，2022 年 4 月]

Enables K48-linked polyubiquitin modification-dependent protein binding activity; Lys48-specific Deubiquitinase activity; and cysteine-type Carboxypeptidase activity. Predicted to be involved in protein K48-linked deubiquitination. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

MINDY1 基因产物(17)

mRNA Protein Name
NM_001040217.3 NP_001035307.2 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 2
NM_001163258.3 NP_001156730.3 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 1
NM_001163259.2 NP_001156731.2 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 4
NM_001163260.2 NP_001156732.2 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 2
NM_001319998.2 NP_001306927.2 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 1
NM_001376664.1 NP_001363593.1 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 5
NM_001376665.1 NP_001363594.1 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 1
NM_001376666.1 NP_001363595.1 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 7
NM_001376667.1 NP_001363596.1 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 8
NM_001376668.1 NP_001363597.1 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 8
NM_001376669.1 NP_001363598.1 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 9
NM_001376670.1 NP_001363599.1 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 10
NM_001376671.1 NP_001363600.1 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 11
NM_001376672.1 NP_001363601.1 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 12
NM_001376673.1 NP_001363602.1 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 12
NM_001376674.1 NP_001363603.1 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 13
NM_018379.5 NP_060849.3 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables K48-linked deubiquitinase activity IDA
IDA: 通过直接分析推断
27292798 GOA
enables K48-linked polyubiquitin modification-dependent protein binding IDA
IDA: 通过直接分析推断
28082312 GOA
enables cysteine-type carboxypeptidase activity IDA
IDA: 通过直接分析推断
27292798 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MINDY1 蛋白结构

MINDY_DUB

MINDY_DUB: MINDY deubiquitinase (143 - 268)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 469 a.a.
蛋白主名 其他名称

ubiquitin carboxyl-terminal hydrolase MINDY-1

MINDY deubiquitinase 1

MINDY1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MINDY1 Q8N5J2 FLJ13057 Homo sapiens Q53SE7
Y2H Prey Pooling
25416956
种属内
MINDY1 Q8N5J2 FLJ13057 Homo sapiens Q53SE7
Y2H Array
25416956
种属内
MINDY1 Q8N5J2 FLJ13057 Homo sapiens Q53SE7
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nipah Virus Encephalitis

Equine Morbillivirus
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08451 MINDY1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus MINDY1 VGNC VGNC:63510
Bos taurus MINDY1 VGNC VGNC:55615
Mus musculus MINDY1 MGD MGI:1922257
Canis familiaris MINDY1 VGNC VGNC:43236
Macaca mulatta MINDY1 VGNC VGNC:74828
Rattus norvegicus MINDY1 RGD RGD:1559660
Others MINDY1 NCBI
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