PTGIS - prostaglandin I2 synthase Gene

中文名称：前列腺素 I2 合酶

种属: Homo sapiens

同用名: CYP8; PGIS; PTGI; CYP8A1

基因 ID: 5740 | 基因类型: protein coding

关于 PTGIS

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:49,503,874-49,568,137 (from NCBI)

This gene has 2 transcripts (splice variants), 250 orthologues, 1 paralogue and is associated with 2 phenotypes. Broad expression in urinary bladder (RPKM 26.9), gall bladder (RPKM 23.0) and 16 other tissues.

功能概要

该基因编码细胞色素 P450 酶超家族的成员。细胞色素 P450 蛋白是单加氧酶，可催化许多涉及药物代谢和胆固醇、类固醇和其他脂质合成的反应。然而，根据序列相似性而非功能相似性，该蛋白质被认为是细胞色素 P450 超家族的成员。这种内质网膜蛋白催化前列腺素 H2 转化为前列环素 (前列腺素 I2) ，前列环素是一种有效的血管扩张剂和血小板聚集抑制剂。前列环素及其生理拮抗剂血栓素 A2 的失衡导致心肌梗塞、中风和动脉粥样硬化的发展。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. However, this protein is considered a member of the Cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]

PTGIS 基因产物(1)

mRNA	Protein	Name
NM_000961.4	NP_000952.1	prostacyclin synthase precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables heme binding	IDA IDA: 通过直接分析推断	17020766	GOA
enables prostaglandin-I synthase activity	IDA IDA: 通过直接分析推断	15115769	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	20122998	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in apoptotic signaling pathway	IDA IDA: 通过直接分析推断	11551955	GOA
involved in cellular response to hypoxia	IDA IDA: 通过直接分析推断	21296955	GOA
involved in cellular response to interleukin-1	IEP IEP: 通过表达模式推断	8185632	GOA
involved in cellular response to interleukin-6	IEP IEP: 通过表达模式推断	8185632	GOA
involved in icosanoid metabolic process	IDA IDA: 通过直接分析推断	15115769	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: 通过直接分析推断	20159982	GOA
involved in negative regulation of inflammatory response	IDA IDA: 通过直接分析推断	20159982	GOA
involved in negative regulation of nitric oxide biosynthetic process	IDA IDA: 通过直接分析推断	20159982	GOA
involved in positive regulation of angiogenesis	IMP IMP: 通过突变表型推断	20122998	GOA
involved in positive regulation of execution phase of apoptosis	IDA IDA: 通过直接分析推断	11551955	GOA
involved in positive regulation of peroxisome proliferator activated receptor signaling pathway	IDA IDA: 通过直接分析推断	11551955	GOA
involved in prostaglandin biosynthetic process	IDA IDA: 通过直接分析推断	15115769	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in caveola	IDA IDA: 通过直接分析推断	20122998	GOA
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	21035466	GOA
located in nucleus	IDA IDA: 通过直接分析推断	21035466	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PTGIS 蛋白结构

p450

0
100
200
300
400
500 a.a.

蛋白主名

其他名称

prostacyclin synthase

cytochrome P450, family 8, subfamily A, polypeptide 1

关联疾病

疾病名称

别名

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Childhood-Onset Schizophrenia

Childhood Schizophrenia

Schizophrenia, Childhood

Pulmonary Hypertension

Primary Pulmonary Hypertension	Hypertension Pulmonary
Hypertension, Pulmonary	Hypertension, Pulmonary, Primary
Idiopathic Pulmonary Hypertension	Idiopathic Pulmonary Arterial Hypertension
Pulmonary Htn - [Hypertension]

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Stroke, Ischemic

Cerebral Infarction	Stroke
Ischemic Stroke	Cerebrovascular Accident
Cerebral Infarction, Susceptibility To	Stroke, Ischemic, Susceptibility To
Cerebral Infarct	Ischemic Stroke, Susceptibility To
Stroke, Susceptibility To	Cva - Cerebral Infarction
ISCHSTR	Ischemic Cerebrovascular Accident

Lung Benign Neoplasm

Lung Neoplasms	Tumor Of The Lung
Lung Tumor

Acute Stress Disorder

Traumatic Stress Disorder	Stress Disorders, Traumatic, Acute
Stress Disorders, Traumatic

Trichothiodystrophy

Ttd	Amish Brittle Hair Syndrome
Bids Syndrome	Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome
Ibids	Pibids
Trichothiodystrophy Syndromes

Post-Traumatic Stress Disorder

PTSD	Traumatic Neurosis
Post Traumatic Stress Disorder	Stress Disorders, Post-Traumatic
Posttraumatic Stress Disorder	Ptsd - [Post Traumatic Stress Disorder]
Trauma-Related Disorders

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11389	PTGIS Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PTGIS	RGD	RGD:3438
Macaca mulatta	PTGIS	VGNC	VGNC:76587
Mus musculus	PTGIS	MGD	MGI:1097156
Canis familiaris	PTGIS	VGNC	VGNC:45149
Bos taurus	PTGIS	VGNC	VGNC:33509
Felis catus	PTGIS	VGNC	VGNC:69146

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PTGIS - prostaglandin I2 synthase Gene

关于 PTGIS

功能概要

PTGIS 基因产物(1)

PTGIS 蛋白结构

关联疾病

直系同源

热门区域

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PTGIS - prostaglandin I2 synthase Gene

关于 PTGIS

功能概要

PTGIS 基因产物(1)

PTGIS 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z