PTPRS - protein tyrosine phosphatase receptor type S Gene

中文名称：S 型蛋白酪氨酸磷酸酶受体

种属: Homo sapiens

同用名: R-PTP-S; PTPSIGMA; R-PTP-sigma

关于 PTPRS

功能概要

该基因编码的蛋白质是蛋白酪氨酸磷酸酶 (PTP) 家族的成员。已知 PTP 是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和致癌转化。该 PTP 包含一个细胞外区域、一个跨膜区段和两个串联的胞质内催化结构域，因此代表受体型 PTP。该蛋白的细胞外区域由多个 Ig 样和 III 型纤连蛋白样结构域组成。对小鼠中相似基因的研究表明，这种 PTP 可能参与胚胎发生过程中的细胞间相互作用、初级轴突发生和轴突导向。该 PTP 也与成人神经修复的分子控制有关。已经报道了编码不同蛋白质的四种选择性剪接的转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]