2. Gene
  3. RALB - RAS like proto-oncogene B Gene

RALB - RAS like proto-oncogene B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RAS 样原癌基因 B

种属: Homo sapiens

基因 ID: 5899 | 基因类型: protein coding

关于 RALB

Cytogenetic location: 2q14.2 Genomic coordinates (GRCh38): 2:120,240,070-120,294,710 (from NCBI)

This gene has 8 transcripts (splice variants), 266 orthologues and 35 paralogues. Ubiquitous expression in esophagus (RPKM 28.5), appendix (RPKM 25.0) and 25 other tissues.

功能概要

该基因编码属于小 GTP 酶超家族和 Ras 蛋白家族的 GTP 结合蛋白。 GTP 结合蛋白介导由某些细胞表面受体的占据启动的跨膜信号传导。[RefSeq 提供，2008 年 7 月]

This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008]

RALB 基因产物(2)

mRNA Protein Name
NM_001369400.1 NP_001356329.1 ras-related protein Ral-B
NM_002881.3 NP_002872.1 ras-related protein Ral-B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATPase binding IPI
IPI: 通过物理相互作用推断
24056301 GOA
enables GDP binding IDA
IDA: 通过直接分析推断
24056301 GOA
enables GTP binding IDA
IDA: 通过直接分析推断
19166349 GOA
enables GTP binding IMP
IMP: 通过突变表型推断
24056301 GOA
enables GTPase activity IDA
IDA: 通过直接分析推断
19166349 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
7673236 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
24056301 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to exogenous dsRNA IMP
IMP: 通过突变表型推断
24056301 GOA
involved in cellular response to starvation IDA
IDA: 通过直接分析推断
24056301 GOA
involved in negative regulation of protein binding IMP
IMP: 通过突变表型推断
24056301 GOA
involved in positive regulation of autophagosome assembly IMP
IMP: 通过突变表型推断
24056301 GOA
involved in positive regulation of epidermal growth factor receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
34096503 GOA
involved in positive regulation of protein binding IMP
IMP: 通过突变表型推断
24056301 GOA
involved in positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
24056301 GOA
involved in positive regulation of protein serine/threonine kinase activity IMP
IMP: 通过突变表型推断
24056301 GOA
involved in receptor internalization IGI
IGI: 通过遗传相互作用推断
34096503 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in midbody IDA
IDA: 通过直接分析推断
18756269 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
17875936 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RALB 蛋白结构

Ras

Ras: Ras family (16 - 177)

  • 0
  • 100
  • 206 a.a.
蛋白主名 其他名称

ras-related protein Ral-B

RALB Ras like proto-oncogene B

RALB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RALB P11234 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
种属内
RALB P11234 INCA1 Homo sapiens Q0VD86
Validated Y2H
32296183
种属内
RALB P11234 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

RALB 抗体

目录号 产品名 应用 反应物种
HY-P82071 RALB Antibody (YA1816) WB, IP Human, Mouse
HY-P84056 RALB Antibody (YA3753) WB, IHC-P, FC, ELISA Human, Mouse, Monkey

关联疾病

疾病名称 别名
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12875 BQU57 Inhibitor 99.45% 否
HY-12873 RBC8 Inhibitor ≥98.0% 否
HY-RS11628 RALB Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus RALB RGD RGD:619852
Macaca mulatta RALB VGNC VGNC:99396
Bos taurus RALB VGNC VGNC:33699
Felis catus RALB VGNC VGNC:69228
Mus musculus RALB MGD MGI:1927244
Canis familiaris RALB VGNC VGNC:45331
Others RALB NCBI
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