2. Gene
  3. RCN1 - reticulocalbin 1 Gene

RCN1 - reticulocalbin 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：网状局部蛋白 1

种属: Homo sapiens

同用名: RCN; RCAL; PIG20; HEL-S-84

基因 ID: 5954 | 基因类型: protein coding

关于 RCN1

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:32,091,074-32,105,722 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 4 paralogues. Ubiquitous expression in placenta (RPKM 69.9), urinary bladder (RPKM 61.7) and 24 other tissues.

功能概要

Reticulocalbin 1 是一种位于 ER 腔内的钙结合蛋白。该蛋白质包含六个与高亲和力 CA (+2) 结合基序 EF 手相似的保守区域。与小鼠网状局部蛋白相比，这些基序之外的氨基酸残基的高度保守性与钙结合之外的可能生化功能一致。在人内皮细胞和前列腺癌细胞系中，这种蛋白质定位于质膜。[RefSeq 提供，2009 年 1 月]

Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity CA(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate Cancer cell lines this protein localizes to the plasma membrane.[provided by RefSeq, Jan 2009]

RCN1 基因产物(1)

mRNA Protein Name
NM_002901.4 NP_002892.1 reticulocalbin-1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16713569 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RCN1 蛋白结构

EF-hand_7

EF-hand_7: EF-hand domain pair (84 - 143)

EF-hand_7

EF-hand_7: EF-hand domain pair (172 - 229)

EF-hand_6

EF-hand_6: EF-hand domain (249 - 273)

  • 0
  • 100
  • 200
  • 300
  • 331 a.a.
蛋白主名 其他名称

reticulocalbin-1

epididymis secretory protein Li 84

RCN1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RCN1 Q15293 ATPAF2 Homo sapiens Q8N5M1
Validated Y2H
32296183
种属内
RCN1 Q15293 ZNF410 Homo sapiens Q86VK4-3
Validated Y2H
32296183
种属内
RCN1 Q15293 LMO3 Homo sapiens Q8TAP4-4
Validated Y2H
32296183
种属内
RCN1 Q15293 FAM110A Homo sapiens Q9BQ89
Validated Y2H
32296183
种属内
RCN1 Q15293 DCAF11 Homo sapiens Q8TEB1
Validated Y2H
32296183
种属内
RCN1 Q15293 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
种属内
RCN1 Q15293 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
种属内
RCN1 Q15293 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
种属内
RCN1 Q15293 GTPBP3 Homo sapiens Q969Y2
Validated Y2H
32296183
种属内
RCN1 Q15293 EFHC1 Homo sapiens Q5JVL4
Validated Y2H
32296183
种属内
RCN1 Q15293 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
种属内
RCN1 Q15293 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
种属内
RCN1 Q15293 ATXN1 Homo sapiens P54253
Y2H
16713569
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 RCN1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71820 RCN1 Protein, Human (P.pastoris, His) Q15293-1 (31P-L331) ≥95%

关联疾病

疾病名称 别名
Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome

Wagr Syndrome

11p Partial Monosomy Syndrome

Chromosome 11p13 Deletion Syndrome

Wilms Tumor, Aniridia, Genitourinary Anomalies And Mental Retardation Syndrome

11p Deletion Syndrome

Chromosome 11p Deletion Syndrome

Wagr Complex

Wilms Tumor-Aniridia-Genitourinary Anomalies-Intellectual Disability Syndrome

Deletion 11p13

WAGR

Wilms Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome

Chromosome 11p Deletion

11p Deletion

11p Monosomy

Deletion 11p

Monosomy 11p

Partial Monosomy 11p

Agr Triad

Wilms Tumor-Aniridia-Gonadoblastoma-Mental Retardation Syndrome

Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation Syndrome

Wagr Contiguous Gene Syndrome

Wilms Tumor-Aniridia-Genital Anomalies-Retardation Syndrome

Wilms Tumor-Aniridia-Genitourinary Anomalies-Mr Syndrome

Del(11)(P13)

Monosomy 11p13

Chromosome 11, Deletion 11p
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Aniridia 1

Aniridia

Congenital Aniridia

AN1

An

Cataract With Late-Onset Corneal Dystrophy

Aplasia Of Iris

Absent Iris

Irideremia

Aniridia Ii, Formerly

An2, Formerly

An2

Aniridia Type Ii

Aniridia, Type 1

An-1

Absence Of Iris

Agenesis Of Iris

Congenital Absence Of Iris

Hereditary Aniridia

Sporadic Aniridia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11779 RCAN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS11788 RCN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19156 Rcn1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21728 Rcan1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25645 Rcn1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus RCN1 MGD MGI:104559
Rattus norvegicus RCN1 RGD RGD:1311292
Bos taurus RCN1 VGNC VGNC:33831
Canis familiaris RCN1 VGNC VGNC:52039
Macaca mulatta RCN1 VGNC VGNC:101389
Felis catus RCN1 VGNC VGNC:81953
Others RCN1 NCBI
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