1. Gene
  2. RNR1 - RNA, ribosomal 45S cluster 1 Gene

RNR1 - RNA, ribosomal 45S cluster 1 Gene

中文名称:RNA,核糖体 45S 簇 1

种属: Homo sapiens

基因 ID: 6052 | 基因类型: other

关于 RNR1

Cytogenetic location: 13p12 Genomic coordinates (GRCh38): 13:4,600,001-10,100,000

功能概要

45S 核糖体 DNA (rDNA) 阵列或簇存在于人类染色体 13、14、15、21 和 22 上,分别指定为 RNR1 至 RNR5。每个簇由多个 45S rDNA 重复单元组成,这些重复单元的数量因个体和染色体而异,人类基因组中的总二倍体拷贝数估计范围为 60 到 >800 个重复单元。 45S rDNA 重复单元编码 45S rRNA 前体,由 RNA 聚合酶 I 转录,经加工形成 18S、5.8S 和 28S rRNA。 Gene 和 RefSeq 与 HGNC 合作,目前描述了一个 45S rDNA 簇,以及一组 45S 前体和产物 rRNA,用于这些基因座定位到的五个人类染色体中的每一个。该基因代表 13 号染色体上的 45S 核糖体 DNA 簇。[RefSeq 提供,2017 年 2 月]

45S ribosomal DNA (rDNA) arrays, or clusters, are present on human chromosomes 13, 14, 15, 21 and 22, designated RNR1 through RNR5, respectively. Each cluster consists of multiple 45S rDNA repeat units that vary in number among individuals and chromosomes, with total diploid copy number estimates ranging from 60 to >800 repeat units in a human genome. The 45S rDNA repeat unit encodes a 45S rRNA precursor, transcribed by RNA polymerase I, which is processed to form the 18S, 5.8S and 28S rRNAs. Gene and RefSeq, in collaboration with HGNC, currently describe one 45S rDNA cluster, and one set of 45S precursor and product rRNAs, for each of the five human chromosomes to which these loci are localized. This gene represents the 45S ribosomal DNA cluster on chromosome 13. [provided by RefSeq, Feb 2017]

关联疾病

疾病名称 别名
Sensorineural Hearing Loss

Sensory Hearing Loss

Sensorineural Deafness

Sensorineural Hearing Loss Disorder

Hearing Loss, Sensorineural

Central Hearing Loss

High Frequency Deafness

High Frequency Hearing Loss

High-Frequency Hearing Loss

Perceptive Deafness

Perceptive Hearing Loss

Perceptive Hearing Loss Or Deafness

Hearing Loss Sensorineural

Deafness Sensorineural

Hearing Loss High-Frequency

Hearing Loss, Central

Hearing Loss, High-Frequency

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris RNR1 NCBI
Mus musculus RNR1 NCBI
Rattus norvegicus RNR1 NCBI