1. Gene
  2. Mthfd1 - methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Gene

Mthfd1 - methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Gene

种属: Rattus norvegicus

基因 ID: 64300 | 基因类型: protein coding

关于 Mthfd1

功能概要

Predicted to enable formate-tetrahydrofolate Ligase activity; methenyltetrahydrofolate cyclohydrolase activity; and methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity. Involved in nucleotide metabolic process; one-carbon metabolic process; and response to nitrogen dioxide. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; cleft lip; developmental cardiac valvular defect; neural tube defect (multiple); and tetralogy of Fallot. Orthologous to human MTHFD1 (methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]

Mthfd1 基因产物(1)

mRNA Protein Name
NM_022508.2 NP_071953.2 C-1-tetrahydrofolate synthase, cytoplasmic
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in one-carbon metabolic process IEP
IEP: 通过表达模式推断
14597174 RGD
involved in response to nitrogen dioxide IEP
IEP: 通过表达模式推断
3264158 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

C-1-tetrahydrofolate synthase, cytoplasmic

C1-THF synthase

C1-tetrahydrofolate synthase

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase

methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetr

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mthfd1 NCBI NCBI:4522