2. Gene
  3. SURF4 - surfeit 4 Gene

SURF4 - surfeit 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：过量 4

种属: Homo sapiens

同用名: ERV29

基因 ID: 6836 | 基因类型: protein coding

关于 SURF4

Cytogenetic location: 9q34.2 Genomic coordinates (GRCh38): 9:133,361,464-133,377,949 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 252 orthologues and 1 paralogue. Ubiquitous expression in duodenum (RPKM 40.0), small intestine (RPKM 39.7) and 25 other tissues.

功能概要

该基因位于过剩基因簇中，该簇由非常紧密相连的管家基因组成，这些管家基因不具有序列相似性。编码的蛋白质是一种保守的整合膜蛋白，可与内质网-高尔基体中间室蛋白相互作用。该基因的破坏导致内质网-高尔基体中间室簇数量减少和外壳蛋白 I 重新分布到胞质溶胶中。交替剪接导致多个转录本变体。[RefSeq 提供，2013 年 7 月]

This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

SURF4 基因产物(7)

mRNA Protein Name
NM_001280788.2 NP_001267717.1 surfeit locus protein 4 isoform 2
NM_001280789.2 NP_001267718.1 surfeit locus protein 4 isoform 3
NM_001280790.2 NP_001267719.1 surfeit locus protein 4 isoform 4
NM_001280791.2 NP_001267720.1 surfeit locus protein 4 isoform 4
NM_001280792.2 NP_001267721.1 surfeit locus protein 4 isoform 5
NM_001280793.2 NP_001267722.1 surfeit locus protein 4 isoform 6
NM_033161.4 NP_149351.1 surfeit locus protein 4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables COPII receptor activity IDA
IDA: 通过直接分析推断
33186557 GOA
enables cargo receptor activity IDA
IDA: 通过直接分析推断
30251625 GOA
enables cargo receptor activity IMP
IMP: 通过突变表型推断
29643117 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18287528 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Golgi organization IMP
IMP: 通过突变表型推断
18287528 GOA
NOT involved in early endosome to Golgi transport IMP
IMP: 通过突变表型推断
18287528 GOA
involved in lipid homeostasis IDA
IDA: 通过直接分析推断
34015269 GOA
involved in lipoprotein transport IDA
IDA: 通过直接分析推断
34015269 GOA
involved in lipoprotein transport IMP
IMP: 通过突变表型推断
29643117 GOA
involved in positive regulation of organelle organization IMP
IMP: 通过突变表型推断
18287528 GOA
NOT involved in protein exit from endoplasmic reticulum IMP
IMP: 通过突变表型推断
18287528 GOA
involved in regulation of lipid transport IDA
IDA: 通过直接分析推断
34015269 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in COPII-coated ER to Golgi transport vesicle IDA
IDA: 通过直接分析推断
33186557 GOA
is active in endoplasmic reticulum exit site IDA
IDA: 通过直接分析推断
33186557 GOA
located in endoplasmic reticulum-Golgi intermediate compartment IDA
IDA: 通过直接分析推断
15308636 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SURF4 蛋白结构

SURF4

SURF4: SURF4 family (4 - 269)

  • 0
  • 100
  • 200
  • 269 a.a.
蛋白主名 其他名称

surfeit locus protein 4

surface 4 integral membrane protein

SURF4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SURF4 O15260 LMAN1 Homo sapiens P49257
Anti Bait CoIP
18287528
种属内
SURF4 O15260 LMAN1 Homo sapiens P49257
Confocal
18287528
种属内
SURF4 O15260 STING1 Homo sapiens Q86WV6
Anti Tag CoIP
21903422
种属间: 跨种属相互作用 种属内: 同种属相互作用

SURF4 抗体

目录号 产品名 应用 反应物种
HY-P82720 Surfeit Locus Protein 4 Antibody (YA2465) WB, ICC/IF Human, Mouse, Rat

关联疾病

疾病名称 别名
Colorectal Cancer, Hereditary Nonpolyposis, Type 2

HNPCC2

Fcc2

Coca2

Hereditary Nonpolyposis Colorectal Cancer Type 2

Colon Cancer, Familial Nonpolyposis, Type 2

Familial Nonpolyposis Colon Cancer Type 2

Hereditary Non-Polyposis Colorectal Cancer 2

Cancer, Colorectal, Nonpolyposis, Hereditary, Type 2
Macular Degeneration, Age-Related, 4

Age Related Macular Degeneration 4

ARMD4

Macular Degeneration, Age-Related, Type 4
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14044 SURF4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus SURF4 VGNC VGNC:106962
Rattus norvegicus SURF4 RGD RGD:1561980
Felis catus SURF4 VGNC VGNC:102990
Canis familiaris SURF4 VGNC VGNC:46996
Mus musculus SURF4 MGD MGI:98445
Macaca mulatta SURF4 VGNC VGNC:78060
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