2. Gene
  3. TAF4B - TATA-box binding protein associated factor 4b Gene

TAF4B - TATA-box binding protein associated factor 4b Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TATA 盒结合蛋白相关因子 4b

种属: Homo sapiens

同用名: SPGF13; TAF2C2; TAFII105

基因 ID: 6875 | 基因类型: protein coding

关于 TAF4B

Cytogenetic location: 18q11.2 Genomic coordinates (GRCh38): 18:26,226,445-26,391,685 (from NCBI)

This gene has 3 transcripts (splice variants), 184 orthologues, 1 paralogue and is associated with 2 phenotypes. Broad expression in testis (RPKM 5.0), lymph node (RPKM 3.4) and 24 other tissues.

功能概要

TATA 结合蛋白 (TBP) 和 TBP 相关因子 (TAF) 参与 TFIID 蛋白复合物的形成，该复合物参与 RNA 聚合酶 II 的基因转录启动。该基因编码一种细胞类型特异性的 TAF，它可能负责介导 B 细胞中激活子子集的转录。已发现该基因编码两种不同亚型的三种转录变体。[RefSeq 提供，2014 年 6 月]

TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

TAF4B 基因产物(2)

mRNA Protein Name
NM_001293725.2 NP_001280654.1 transcription initiation factor TFIID subunit 4B isoform 1
NM_005640.3 NP_005631.1 transcription initiation factor TFIID subunit 4B isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
15601843 GOA
enables NF-kappaB binding IPI
IPI: 通过物理相互作用推断
10849440 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mRNA transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
17884155 GOA
involved in positive regulation of transcription initiation by RNA polymerase II IDA
IDA: 通过直接分析推断
17884155 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of transcription factor TFIID complex IDA
IDA: 通过直接分析推断
29111974 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TAF4B 蛋白结构

TAFH

TAFH: NHR1 homology to TAF (257 - 350)

TAF4

TAF4: Transcription initiation factor TFIID component TAF4 family (616 - 859)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 862 a.a.
蛋白主名 其他名称

transcription initiation factor TFIID subunit 4B

TAF(II)105

关联疾病

疾病名称 别名
Spermatogenic Failure 13

SPGF13
Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Vas Deferens, Congenital Bilateral Aplasia Of

Congenital Bilateral Absence Of Vas Deferens

CBAVD

Cavd

Congenital Bilateral Aplasia Of Vas Deferens

Congenital Bilateral Absence Of The Vas Deferens

Congenital Bilateral Agenesis Of Vas Deferens

Absence Of Vas Deferens

Absent Vasa

Congenital Absence Of Vas Deferens

Congenital Aplasia Of Vas Deferens

Absent Vas Deferens

Vas Deferens, Congenital Bilateral Absence
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14170 TAF4B Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TAF4B RGD RGD:1562997
Felis catus TAF4B VGNC VGNC:65932
Bos taurus TAF4B VGNC VGNC:35575
Canis familiaris TAF4B VGNC VGNC:47082
Mus musculus TAF4B MGD MGI:2152345
Macaca mulatta TAF4B VGNC VGNC:78091
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