2. Gene
  3. Wnk4 - WNK lysine deficient protein kinase 4 Gene

Wnk4 - WNK lysine deficient protein kinase 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Pha2b; Prkwnk4; 2010002J11Rik

基因 ID: 69847 | 基因类型: protein coding

关于 Wnk4

功能概要

Predicted to enable Chloride Channel Inhibitor activity; Potassium Channel Inhibitor activity; and protein serine/threonine kinase activity. Involved in ion transport. Acts upstream of or within chloride transport; negative regulation of pancreatic juice secretion; and protein localization. Located in bicellular tight junction and cytoplasm. Is expressed in several structures, including alimentary system; metanephros; metatarsal bone; sensory organ; and turbinate bone primordium. Used to study Gitelman syndrome and pseudohypoaldosteronism. Human ortholog(s) of this gene implicated in hypertension and pseudohypoaldosteronism. Orthologous to human WNK4 (WNK lysine deficient protein kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Wnk4 基因产物(1)

mRNA Protein Name
NM_175638.3 NP_783569.1 serine/threonine-protein kinase WNK4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chloride ion binding IMP
IMP: 通过突变表型推断
30765526 MGI
enables ion channel inhibitor activity IDA
IDA: 通过直接分析推断
14608358 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17360471 MGI
enables protein serine/threonine kinase activity IMP
IMP: 通过突变表型推断
21486947 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
22114204 MGI
involved in activation of protein kinase activity IDA
IDA: 通过直接分析推断
28096417 MGI
involved in aldosterone secretion IMP
IMP: 通过突变表型推断
22550170 MGI
involved in calcium ion homeostasis IMP
IMP: 通过突变表型推断
31496133 MGI
involved in cellular response to xenobiotic stimulus IMP
IMP: 通过突变表型推断
31496133 MGI
acts upstream of or within chloride transport IDA
IDA: 通过直接分析推断
14769928 MGI
involved in gene expression IGI
IGI: 通过遗传相互作用推断
28743496 MGI
involved in gene expression IMP
IMP: 通过突变表型推断
22114204 MGI
involved in inflammatory response IMP
IMP: 通过突变表型推断
31786261 MGI
involved in intracellular chloride ion homeostasis IMP
IMP: 通过突变表型推断
30765526 MGI
involved in macrophage activation IMP
IMP: 通过突变表型推断
31786261 MGI
involved in monoatomic ion homeostasis IMP
IMP: 通过突变表型推断
23576762 MGI
acts upstream of or within negative regulation of pancreatic juice secretion IMP
IMP: 通过突变表型推断
21317537 MGI
involved in negative regulation of protein kinase activity IMP
IMP: 通过突变表型推断
30765526 MGI
involved in negative regulation of protein localization to plasma membrane IDA
IDA: 通过直接分析推断
17673510 MGI
involved in potassium ion transmembrane transport IMP
IMP: 通过突变表型推断
28365586 MGI
acts upstream of or within protein localization IDA
IDA: 通过直接分析推断
12515852 MGI
involved in protein phosphorylation IGI
IGI: 通过遗传相互作用推断
28743496 MGI
involved in protein phosphorylation IMP
IMP: 通过突变表型推断
22114204 MGI
involved in regulation of blood pressure IMP
IMP: 通过突变表型推断
16964266 MGI
involved in regulation of potassium ion export across plasma membrane IMP
IMP: 通过突变表型推断
16964266 MGI
involved in regulation of protein kinase activity IMP
IMP: 通过突变表型推断
29921588 MGI
involved in renal sodium ion absorption IMP
IMP: 通过突变表型推断
16964266 MGI
involved in renal sodium ion transport IDA
IDA: 通过直接分析推断
14608358 MGI
involved in response to dietary excess IMP
IMP: 通过突变表型推断
22550170 MGI
involved in response to xenobiotic stimulus IGI
IGI: 通过遗传相互作用推断
24039833 MGI
involved in signal transduction IMP
IMP: 通过突变表型推断
21486947 MGI
involved in sodium ion transmembrane transport IMP
IMP: 通过突变表型推断
24655003 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in bicellular tight junction IDA
IDA: 通过直接分析推断
11498583 MGI
is active in cell body IMP
IMP: 通过突变表型推断
31736353 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
14769928 MGI
part of protein-containing complex IDA
IDA: 通过直接分析推断
25113964 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

serine/threonine-protein kinase WNK4

protein kinase with no lysine 4

protein kinase, lysine deficient 4

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100626 WNK463 Inhibitor 99.75% 否
HY-112143 STOCK2S-26016 Inhibitor 98.7% 否
HY-RS15826 WNK4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18506 Wnk4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24988 Wnk4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Wnk4 NCBI NCBI:65266
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