2. Gene
  3. UBE2B - ubiquitin conjugating enzyme E2 B Gene

UBE2B - ubiquitin conjugating enzyme E2 B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：泛素结合酶 E2 B

种属: Homo sapiens

同用名: HR6B; UBC2; HHR6B; RAD6B; E2-17kDa

基因 ID: 7320 | 基因类型: protein coding

关于 UBE2B

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:134,371,569-134,392,108 (from NCBI)

This gene has 8 transcripts (splice variants), 223 orthologues and 24 paralogues. Ubiquitous expression in adrenal (RPKM 31.0), heart (RPKM 26.8) and 25 other tissues.

功能概要

用泛素修饰蛋白质是靶向异常或短寿命蛋白质进行降解的重要细胞机制。泛素化至少涉及三类酶：泛素激活酶或 E1、泛素结合酶或 E2，以及泛素-蛋白质连接酶或 E3。该基因编码 E2 泛素结合酶家族的成员。这种酶是复制后 DNA 损伤修复所必需的。其蛋白质序列与小鼠、大鼠和兔的同系物 100% 相同，表明该酶在真核生物进化中高度保守。[RefSeq 提供，2008 年 7 月]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]

UBE2B 基因产物(2)

mRNA Protein Name
NM_003337.4 NP_003328.1 ubiquitin-conjugating enzyme E2 B
NM_003337.4 NP_003328.1 ubiquitin-conjugating enzyme E2 B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12776193 GOA
enables ubiquitin conjugating enzyme activity IDA
IDA: 通过直接分析推断
38182926 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
10908344 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
10373550 GOA
enables ubiquitin-protein transferase activity IMP
IMP: 通过突变表型推断
18339854 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IDA
IDA: 通过直接分析推断
14981545 GOA
involved in DNA repair IGI
IGI: 通过遗传相互作用推断
1717990 GOA
involved in postreplication repair IDA
IDA: 通过直接分析推断
14981545 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
10373550 GOA
involved in protein K11-linked ubiquitination IDA
IDA: 通过直接分析推断
20061386 GOA
involved in protein K48-linked ubiquitination IDA
IDA: 通过直接分析推断
20061386 GOA
involved in protein K63-linked ubiquitination IDA
IDA: 通过直接分析推断
20061386 GOA
involved in protein autoubiquitination IDA
IDA: 通过直接分析推断
19123975 GOA
involved in protein stabilization IMP
IMP: 通过突变表型推断
18339854 GOA
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
10373550 GOA
involved in response to UV IGI
IGI: 通过遗传相互作用推断
1717990 GOA
involved in response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
14981545 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
10373550 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of HULC complex IDA
IDA: 通过直接分析推断
19410543 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
18339854 GOA
located in nucleus IDA
IDA: 通过直接分析推断
18339854 GOA
located in replication fork IDA
IDA: 通过直接分析推断
18363965 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UBE2B 蛋白结构

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (8 - 143)

  • 0
  • 100
  • 152 a.a.
蛋白主名 其他名称

ubiquitin-conjugating enzyme E2 B

E2 protein

UBE2B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
UBE2B P63146 RAD18 Homo sapiens Q9NS91
X-Ray Diffraction
21422291
种属内
UBE2B P63146 RAD18 Homo sapiens Q9NS91
NMR
21422291
种属内
UBE2B P63146 RAD18 Homo sapiens Q9NS91
Anti Tag CoIP
33961781
种属内
UBE2B P63146 RAD18 Homo sapiens Q9NS91
SPR
21422291
种属内
UBE2B P63146 RAD18 Homo sapiens Q9NS91
Anti Tag CoIP
28514442
种属内
UBE2B P63146 HERPUD2 Homo sapiens Q9BSE4
Y2H Array
32296183
种属内
UBE2B P63146 HERPUD2 Homo sapiens Q9BSE4
Validated Y2H
32296183
种属内
UBE2B P63146 HERPUD2 Homo sapiens Q9BSE4
Y2H Prey Pooling
32296183
种属内
UBE2B P63146 H2AC25 Homo sapiens Q7L7L0
Pull Down
20080676
种属内
UBE2B P63146 UBR1 Homo sapiens Q8IWV7
NMR
21422291
种属内
UBE2B P63146 UBR1 Homo sapiens Q8IWV7
Y2H Pooling
16169070
种属内
UBE2B P63146 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
种属内
UBE2B P63146 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
种属内
UBE2B P63146 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 UBE2B 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71398 UBE2B Protein, Human (HEK293, His) P63146 (M1-S152) ≥95%

关联疾病

疾病名称 别名
Halothane Hepatitis

Hepatitis Halothane
Johanson-Blizzard Syndrome

JBS

Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia, And Congenital Deafness

Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia And Congenital Deafness

Johanson Blizzard Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15337 UBE2B Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20506 Ube2b Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27014 Ube2b Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta UBE2B VGNC VGNC:78692
Canis familiaris UBE2B VGNC VGNC:56072
Bos taurus UBE2B VGNC VGNC:36577
Rattus norvegicus UBE2B RGD RGD:708345
Mus musculus UBE2B MGD MGI:102944
Felis catus UBE2B VGNC VGNC:102356
Others UBE2B NCBI
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