1. Gene
  2. UBE2D1 - ubiquitin conjugating enzyme E2 D1 Gene

UBE2D1 - ubiquitin conjugating enzyme E2 D1 Gene

中文名称:泛素结合酶 E2 D1

种属: Homo sapiens

同用名: SFT; UBCH5; UBC4/5; UBCH5A; E2(17)KB1

基因 ID: 7321 | 基因类型: protein coding

关于 UBE2D1

Cytogenetic location: 10q21.1 Genomic coordinates (GRCh38): 10:58,335,006-58,370,748 (from NCBI)

This gene has 4 transcripts (splice variants), 274 orthologues and 12 paralogues. Ubiquitous expression in bone marrow (RPKM 16.4), appendix (RPKM 13.7) and 25 other tissues.

功能概要

用泛素修饰蛋白质是靶向异常或短寿命蛋白质进行降解的重要细胞机制。泛素化至少涉及三类酶:泛素激活酶或 E1、泛素结合酶或 E2,以及泛素-蛋白质连接酶或 E3。该基因编码 E2 泛素结合酶家族的成员。这种酶与铁转运刺激物 (SFT) 密切相关,在遗传性血色素沉着症中上调。它还通过与 E1 泛素激活酶和 E3 泛素蛋白连接酶相互作用,在肿瘤抑制蛋白 p53 和缺氧诱导转录因子 HIF1alpha 的泛素化中发挥作用。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供,2011 年 3 月]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

UBE2D1 基因产物(2)

mRNA Protein Name
NM_001204880.2 NP_001191809.1 ubiquitin-conjugating enzyme E2 D1 isoform 2
NM_003338.5 NP_003329.1 ubiquitin-conjugating enzyme E2 D1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables ubiquitin conjugating enzyme activity IDA
IDA: 通过直接分析推断
15247280 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
8530467 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
18359941 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of TORC1 signaling IDA
IDA: 通过直接分析推断
35927303 GOA
involved in positive regulation of protein ubiquitination IDA
IDA: 通过直接分析推断
16275645 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
35927303 GOA
involved in protein K48-linked ubiquitination IDA
IDA: 通过直接分析推断
20061386 GOA
involved in protein polyubiquitination IDA
IDA: 通过直接分析推断
15247280 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
16275645 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
18845142 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
22797923 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

UBE2D1 蛋白结构

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (5 - 141)

  • 0
  • 100
  • 147 a.a.
蛋白主名 其他名称

ubiquitin-conjugating enzyme E2 D1

(E3-independent) E2 ubiquitin-conjugating enzyme D1

UBE2D1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
UBE2D1 P51668 MID2 Homo sapiens Q9UJV3-2 25416956
种属内
UBE2D1 P51668 MID2 Homo sapiens Q9UJV3-2 32296183
种属内
UBE2D1 P51668 MID2 Homo sapiens Q9UJV3-2 32296183
种属内
UBE2D1 P51668 MID2 Homo sapiens Q9UJV3-2 25416956
种属内
UBE2D1 P51668 MID2 Homo sapiens Q9UJV3-2 32296183
种属内
UBE2D1 P51668 OTUB1 Homo sapiens Q96FW1 32296183
种属内
UBE2D1 P51668 OTUB1 Homo sapiens Q96FW1
Y2H
19549727
种属内
UBE2D1 P51668 OTUB1 Homo sapiens Q96FW1 22124327
种属内
UBE2D1 P51668 OTUB1 Homo sapiens Q96FW1 32296183
种属内
UBE2D1 P51668 OTUB1 Homo sapiens Q96FW1 33961781
种属内
UBE2D1 P51668 OTUB1 Homo sapiens Q96FW1 32296183
种属内
UBE2D1 P51668 TRIM39 Homo sapiens Q9HCM9-2 32296183
种属内
UBE2D1 P51668 TRIM39 Homo sapiens Q9HCM9-2 32296183
种属内
UBE2D1 P51668 TRIM39 Homo sapiens Q9HCM9-2 32296183
种属内
UBE2D1 P51668 CHFR Homo sapiens Q96EP1-2 32296183
种属内
UBE2D1 P51668 CHFR Homo sapiens Q96EP1-2 32296183
种属内
UBE2D1 P51668 CHFR Homo sapiens Q96EP1-2 32296183
种属内
UBE2D1 P51668 MEOX2 Homo sapiens Q6FHY5 32296183
种属内
UBE2D1 P51668 MEOX2 Homo sapiens Q6FHY5 32296183
种属内
UBE2D1 P51668 MEOX2 Homo sapiens Q6FHY5 32296183
种属内
UBE2D1 P51668 RNF181 Homo sapiens Q9P0P0 32296183
种属内
UBE2D1 P51668 RNF181 Homo sapiens Q9P0P0 19690564
种属内
UBE2D1 P51668 RNF181 Homo sapiens Q9P0P0 32296183
种属内
UBE2D1 P51668 RNF181 Homo sapiens Q9P0P0 32296183
种属内
UBE2D1 P51668 RNF111 Homo sapiens Q6ZNA4 19549727
种属内
UBE2D1 P51668 RNF111 Homo sapiens Q6ZNA4 25416956
种属内
UBE2D1 P51668 RNF111 Homo sapiens Q6ZNA4 25416956
种属内
UBE2D1 P51668 RNF25 Homo sapiens Q96BH1 32296183
种属内
UBE2D1 P51668 RNF25 Homo sapiens Q96BH1 32296183
种属内
UBE2D1 P51668 RNF25 Homo sapiens Q96BH1 33961781
种属内
UBE2D1 P51668 RNF25 Homo sapiens Q96BH1 32296183
种属内
UBE2D1 P51668 RNF25 Homo sapiens Q96BH1 19690564
种属内
UBE2D1 P51668 RNF115 Homo sapiens Q9Y4L5 32296183
种属内
UBE2D1 P51668 RNF115 Homo sapiens Q9Y4L5 19690564
种属内
UBE2D1 P51668 RNF115 Homo sapiens Q9Y4L5 32296183
种属内
UBE2D1 P51668 RNF115 Homo sapiens Q9Y4L5 31515488
种属内
UBE2D1 P51668 RNF115 Homo sapiens Q9Y4L5 25416956
种属内
UBE2D1 P51668 RNF115 Homo sapiens Q9Y4L5 32296183
种属内
UBE2D1 P51668 ZNRF1 Homo sapiens Q8ND25 19690564
种属内
UBE2D1 P51668 ZNRF1 Homo sapiens Q8ND25 32296183
种属内
UBE2D1 P51668 ZNRF1 Homo sapiens Q8ND25 32296183
种属内
UBE2D1 P51668 ZNRF1 Homo sapiens Q8ND25 32296183
种属内
UBE2D1 P51668 TRIM3 Homo sapiens O75382 32296183
种属内
UBE2D1 P51668 TRIM3 Homo sapiens O75382 32296183
种属内
UBE2D1 P51668 RNF182 Homo sapiens Q8N6D2 32296183
种属内
UBE2D1 P51668 RNF182 Homo sapiens Q8N6D2 32296183
种属内
UBE2D1 P51668 RNF182 Homo sapiens Q8N6D2 32296183
种属内
UBE2D1 P51668 RNF14 Homo sapiens Q9UBS8 25416956
种属内
UBE2D1 P51668 RNF14 Homo sapiens Q9UBS8 25416956
种属内
UBE2D1 P51668 TRIM54 Homo sapiens Q9BYV2 32296183
种属内
UBE2D1 P51668 TRIM54 Homo sapiens Q9BYV2 32296183
种属内
UBE2D1 P51668 TRIM54 Homo sapiens Q9BYV2 32296183
种属内
UBE2D1 P51668 RNF185 Homo sapiens Q96GF1 32296183
种属内
UBE2D1 P51668 RNF185 Homo sapiens Q96GF1 32296183
种属内
UBE2D1 P51668 RNF185 Homo sapiens Q96GF1 32296183
种属内
UBE2D1 P51668 DTX3 Homo sapiens Q8N9I9 32296183
种属内
UBE2D1 P51668 DTX3 Homo sapiens Q8N9I9 32296183
种属内
UBE2D1 P51668 DTX3 Homo sapiens Q8N9I9 32296183
种属内
UBE2D1 P51668 MKRN3 Homo sapiens Q13064 25416956
种属内
UBE2D1 P51668 MKRN3 Homo sapiens Q13064 25416956
种属内
UBE2D1 P51668 MID1 Homo sapiens O15344 32296183
种属内
UBE2D1 P51668 MID1 Homo sapiens O15344 25416956
种属内
UBE2D1 P51668 MID1 Homo sapiens O15344 32296183
种属内
UBE2D1 P51668 MID1 Homo sapiens O15344 25416956
种属内
UBE2D1 P51668 TRIM8 Homo sapiens Q9BZR9 19549727
种属内
UBE2D1 P51668 TRIM8 Homo sapiens Q9BZR9 32296183
种属内
UBE2D1 P51668 TRIM8 Homo sapiens Q9BZR9 32296183
种属内
UBE2D1 P51668 TRIM8 Homo sapiens Q9BZR9 32296183
种属内
UBE2D1 P51668 MKRN2 Homo sapiens Q9H000 25416956
种属内
UBE2D1 P51668 MKRN2 Homo sapiens Q9H000 32296183
种属内
UBE2D1 P51668 MKRN2 Homo sapiens Q9H000 32296183
种属内
UBE2D1 P51668 MKRN2 Homo sapiens Q9H000 32296183
种属内
UBE2D1 P51668 ARRDC3 Homo sapiens Q96B67 32296183
种属内
UBE2D1 P51668 ARRDC3 Homo sapiens Q96B67 32296183
种属内
UBE2D1 P51668 ARRDC3 Homo sapiens Q96B67 32296183
种属内
UBE2D1 P51668 RNF5 Homo sapiens Q99942 32296183
种属内
UBE2D1 P51668 RNF5 Homo sapiens Q99942 32296183
种属内
UBE2D1 P51668 RNF5 Homo sapiens Q99942 25416956
种属内
UBE2D1 P51668 RNF5 Homo sapiens Q99942 32296183
种属内
UBE2D1 P51668 VCP Homo sapiens P55072 32814053
种属内
UBE2D1 P51668 VCP Homo sapiens P55072 32814053
种属内
UBE2D1 P51668 VCP Homo sapiens P55072 32814053
种属内
UBE2D1 P51668 RNF126 Homo sapiens Q9BV68
Y2H
19549727
种属内
UBE2D1 P51668 RNF126 Homo sapiens Q9BV68 16189514
种属内
UBE2D1 P51668 RNF126 Homo sapiens Q9BV68 25416956
种属内
UBE2D1 P51668 RNF126 Homo sapiens Q9BV68 25416956
种属内
UBE2D1 P51668 RNF126 Homo sapiens Q9BV68 31515488
种属内
UBE2D1 P51668 RNF126 Homo sapiens Q9BV68 19549727
种属内
UBE2D1 P51668 TRAF6 Homo sapiens Q9Y4K3 19549727
种属内
UBE2D1 P51668 MKRN1 Homo sapiens Q9UHC7 32296183
种属内
UBE2D1 P51668 MKRN1 Homo sapiens Q9UHC7 32296183
种属内
UBE2D1 P51668 MKRN1 Homo sapiens Q9UHC7 32296183
种属内
UBE2D1 P51668 RNF11 Homo sapiens Q9Y3C5 19549727
种属内
UBE2D1 P51668 RNF11 Homo sapiens Q9Y3C5 19549727
种属内
UBE2D1 P51668 RNF11 Homo sapiens Q9Y3C5 32296183
种属内
UBE2D1 P51668 RNF11 Homo sapiens Q9Y3C5
Y2H
19549727
种属内
UBE2D1 P51668 RNF11 Homo sapiens Q9Y3C5 32296183
种属内
UBE2D1 P51668 RNF11 Homo sapiens Q9Y3C5 32296183
种属内
UBE2D1 P51668 XIAP Homo sapiens P98170 32296183
种属内
UBE2D1 P51668 XIAP Homo sapiens P98170 17318174
种属内
UBE2D1 P51668 XIAP Homo sapiens P98170 32296183
种属内
UBE2D1 P51668 XIAP Homo sapiens P98170 32296183
种属内
UBE2D1 P51668 XIAP Homo sapiens P98170 19549727
种属内
UBE2D1 P51668 TRIM62 Homo sapiens Q9BVG3 32296183
种属内
UBE2D1 P51668 TRIM62 Homo sapiens Q9BVG3 32296183
种属内
UBE2D1 P51668 TRIM62 Homo sapiens Q9BVG3 32296183
种属内
UBE2D1 P51668 RNF10 Homo sapiens Q8N5U6 33961781
种属内
UBE2D1 P51668 RNF2 Homo sapiens Q99496 19549727
种属内
UBE2D1 P51668 RNF2 Homo sapiens Q99496 32296183
种属内
UBE2D1 P51668 RNF2 Homo sapiens Q99496 32296183
种属内
UBE2D1 P51668 RNF2 Homo sapiens Q99496 32296183
种属内
UBE2D1 P51668 RNF114 Homo sapiens Q9Y508 33961781
种属内
UBE2D1 P51668 TRIM39 Homo sapiens Q9HCM9 25416956
种属内
UBE2D1 P51668 TRIM39 Homo sapiens Q9HCM9 16189514
种属内
UBE2D1 P51668 DTX2 Homo sapiens Q86UW9 32296183
种属内
UBE2D1 P51668 DTX2 Homo sapiens Q86UW9 32296183
种属内
UBE2D1 P51668 DTX2 Homo sapiens Q86UW9 32296183
种属内
UBE2D1 P51668 UBTD1 Homo sapiens Q9HAC8 32296183
种属内
UBE2D1 P51668 UBTD1 Homo sapiens Q9HAC8 32296183
种属内
UBE2D1 P51668 UBTD1 Homo sapiens Q9HAC8 32296183
种属内
UBE2D1 P51668 RING1 Homo sapiens Q06587 19549727
种属内
UBE2D1 P51668 RING1 Homo sapiens Q06587 32296183
种属内
UBE2D1 P51668 RING1 Homo sapiens Q06587 32296183
种属内
UBE2D1 P51668 RING1 Homo sapiens Q06587 32296183
种属内
UBE2D1 P51668 TRIM50 Homo sapiens Q86XT4 32296183
种属内
UBE2D1 P51668 TRIM50 Homo sapiens Q86XT4 32296183
种属内
UBE2D1 P51668 TRIM50 Homo sapiens Q86XT4 32296183
种属间
UBE2D1 P51668 RPS27A Bos taurus P62990 21857666
种属间
UBE2D1 P51668 RPS27A Bos taurus P62990 21857666
种属间
UBE2D1 P51668 Rnf4 Rattus norvegicus O88846 21857666
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 UBE2D1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71399 UBE2D1 Protein, Human (GST) P51668 (M1-M147) ≥95%

UBE2D1 抗体

目录号 产品名 应用 反应物种
HY-P83493 SFT Antibody (YA3238) WB, IHC-P, IP Human, Mouse

关联疾病

疾病名称 别名
Tonne-Kalscheuer Syndrome

TOKAS

Mrx61

Intellectual Developmental Disorder With Or Without Hand And Foot Anomalies, Genital Anomalies, Or Congenital Diaphragmatic Hernia

Mental Retardation, X-Linked 61

X-Linked Mental Retardation 61

Long Qt Syndrome

Romano-Ward Syndrome

Long Q-T Syndrome

Lqt

Qt Syndrome, Long

Congenital Long Qt Syndrome

Familial Long Qt Syndrome

Charcot-Marie-Tooth Disease

Cmt

Hmsn

Hereditary Motor And Sensory Neuropathy

Pma

Cmt - Charcot-Marie-Tooth Disease

Charcot Marie Tooth Disease

Charcot-Marie-Tooth Hereditary Neuropathy

Charcot-Marie-Tooth Syndrome

Peroneal Muscular Atrophy

Hereditary Motor And Sensory Neuropathies

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris UBE2D1 VGNC VGNC:48050
Macaca mulatta UBE2D1 VGNC VGNC:78693
Felis catus UBE2D1 VGNC VGNC:66758
Rattus norvegicus UBE2D1 RGD RGD:1307886
Mus musculus UBE2D1 MGD MGI:2384911
Bos taurus UBE2D1 VGNC VGNC:36579
Others UBE2D1 NCBI