2. Gene
  3. Kmt2b - lysine (K)-specific methyltransferase 2B Gene

Kmt2b - lysine (K)-specific methyltransferase 2B Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Mll2; Wbp7; mKIAA0304; 2610014H22Rik

基因 ID: 75410 | 基因类型: protein coding

关于 Kmt2b

功能概要

Predicted to enable Histone Methyltransferase activity (H3-K4 specific); unmethylated CpG binding activity; and zinc ion binding activity. Acts upstream of or within several processes, including DNA methylation-dependent heterochromatin assembly; female gamete generation; and histone H3-K4 trimethylation. Predicted to be located in nucleus. Predicted to be part of Histone Methyltransferase complex. Is expressed in several structures, including alimentary system; inner cell mass; nervous system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; dystonia; and hepatocellular carcinoma. Orthologous to human KMT2B (lysine methyltransferase 2B). [provided by Alliance of Genome Resources, Apr 2022]

Kmt2b 基因产物(2)

mRNA Protein Name
NM_001290573.1 NP_001277502.1 histone-lysine N-methyltransferase 2B isoform 1
NM_029274.2 NP_083550.2 histone-lysine N-methyltransferase 2B isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone H3K4 methyltransferase activity IDA
IDA: 通过直接分析推断
33766931 MGI
enables histone H3K4 methyltransferase activity IMP
IMP: 通过突变表型推断
20808952 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA methylation-dependent heterochromatin formation IMP
IMP: 通过突变表型推断
20808952 MGI
acts upstream of or within maternal-to-zygotic transition of gene expression IMP
IMP: 通过突变表型推断
20808952 MGI
acts upstream of or within oocyte development IMP
IMP: 通过突变表型推断
20808952 MGI
acts upstream of or within ovarian follicle development IMP
IMP: 通过突变表型推断
20808952 MGI
acts upstream of or within ovulation IMP
IMP: 通过突变表型推断
20808952 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

histone-lysine N-methyltransferase 2B

WBP-7

WW domain binding protein 7

histone-lysine N-methyltransferase MLL4

lysine N-methyltransferase 2B

mixed lineage leukemia 2

myeloid/lymphoid or mixed-lineage leukemia protein 4 homolog

trithorax homolog 2

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07402 KMT2B Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17767 Kmt2d Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20975 Kmt2b Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27492 Kmt2b Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Kmt2b NCBI NCBI:9757
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