FBXL18 - F-box and leucine rich repeat protein 18 Gene

中文名称：F-box 和富亮氨酸的重复蛋白 18

种属: Homo sapiens

同用名: Fbl18

关于 FBXL18

功能概要

由该基因编码的蛋白质是包含大约 40 个氨基酸的 F-box 基序的蛋白质家族的成员。该基序对于与 SKP1 的相互作用以及针对某些蛋白质进行降解非常重要。编码的蛋白质已被证明可以控制 FBXL7 的细胞水平，FBXL7 是一种诱导有丝分裂停滞的蛋白质，通过将其靶向多泛素化和蛋白酶体降解。 F-box 蛋白家族的成员，例如 FBXL18，以大约 40 个氨基酸的 F-box 基序为特征。 F-box 蛋白通过 F-box 与 SKP1 相互作用，并且它们通过其他蛋白质相互作用域与泛素化靶标相互作用。[RefSeq 提供，2016 年 3 月]

The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through Other protein interaction domains. [provided by RefSeq, Mar 2016]