1. Gene
  2. SCUBE1 - signal peptide, CUB domain and EGF like domain containing 1 Gene

SCUBE1 - signal peptide, CUB domain and EGF like domain containing 1 Gene

中文名称:含信号肽、CUB 域和 EGF 样域 1

种属: Homo sapiens

基因 ID: 80274 | 基因类型: protein coding

关于 SCUBE1

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:43,197,280-43,343,372 (from NCBI)

This gene has 7 transcripts (splice variants), 205 orthologues and 2 paralogues. Broad expression in ovary (RPKM 8.0), testis (RPKM 5.9) and 17 other tissues.

功能概要

该基因编码的细胞表面糖蛋白是 SCUBE (信号肽、CUB 结构域、EGF (表皮生长因子) 样蛋白) 家族的成员。家族成员有一个氨基末端信号肽、九个 EGF 样重复序列拷贝和一个位于羧基末端的 CUB 结构域。这种蛋白质在血小板和内皮细胞中表达,可能在血管生物学中发挥重要作用。[RefSeq 提供,2011 年 10 月]

This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology. [provided by RefSeq, Oct 2011]

SCUBE1 基因产物(1)

mRNA Protein Name
NM_173050.5 NP_766638.2 signal peptide, CUB and EGF-like domain-containing protein 1 precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IDA
IDA: 通过直接分析推断
12270931 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
12270931 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12270931 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
12270931 GOA
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
12270931 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
12270931 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
12270931 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SCUBE1 蛋白结构

EGF_3

EGF_3: EGF domain (37 - 72)

cEGF

cEGF: Complement Clr-like EGF-like (98 - 120)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (121 - 156)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (245 - 280)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (286 - 321)

EGF_CA

EGF_CA: Calcium-binding EGF domain (323 - 353)

EGF_CA

EGF_CA: Calcium-binding EGF domain (362 - 399)

Ephrin_rec_like

Ephrin_rec_like: Putative ephrin-receptor like (636 - 683)

Ephrin_rec_like

Ephrin_rec_like: Putative ephrin-receptor like (690 - 737)

Ephrin_rec_like

Ephrin_rec_like: Putative ephrin-receptor like (746 - 793)

CUB

CUB: CUB domain (798 - 907)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 988 a.a.
蛋白主名 其他名称

signal peptide, CUB and EGF-like domain-containing protein 1

signal peptide, CUB domain, EGF-like 1

关联疾病

疾病名称 别名
Mixed Receptive-Expressive Language Disorder
Crimean-Congo Hemorrhagic Fever

Crimean Hemorrhagic Fever

Cchf

Congo Hemorrhagic Fever

Hemorrhagic Fever, Crimean

Chf Congo Virus

Congo-Crimean Hemorrhagic Fever

Congo Fever

Hemorrhagic Fever Crimean-Congo

Cchf - [Crimean-Congo Haemorrhagic Fever]

Kara Mikh Typhoid Fever

Xīnjiāng Haemorrhagic Fever

Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

Star Syndrome

Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome

Syndactyly With Renal And Anogenital Malformations

STAR

Syndactyly, Telecanthus, Anogenital And Renal Malformations

Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SCUBE1 RGD RGD:1309015
Bos taurus SCUBE1 VGNC VGNC:34371
Canis familiaris SCUBE1 VGNC VGNC:45935
Macaca mulatta SCUBE1 VGNC VGNC:77008
Mus musculus SCUBE1 MGD MGI:1890616