2. Gene
  3. ATIC - Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Gene

ATIC - Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 81643 | 基因类型: protein coding

关于 ATIC

功能概要

Enables IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Involved in several processes, including animal organ development; folic acid-containing compound metabolic process; and nucleobase-containing small molecule metabolic process. Predicted to be located in plasma membrane. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase). [provided by Alliance of Genome Resources, Apr 2022]

ATIC 基因产物(1)

mRNA Protein Name
NM_031014.2 NP_112276.2 bifunctional purine biosynthesis protein ATIC
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables IMP cyclohydrolase activity IDA
IDA: 通过直接分析推断
9332377 RGD
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity IDA
IDA: 通过直接分析推断
9332377 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
25687571 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in 'de novo' IMP biosynthetic process IDA
IDA: 通过直接分析推断
9332377 RGD
involved in animal organ regeneration IEP
IEP: 通过表达模式推断
9332377 RGD
involved in brainstem development IEP
IEP: 通过表达模式推断
7057182 RGD
involved in cerebellum development IEP
IEP: 通过表达模式推断
7057182 RGD
involved in cerebral cortex development IEP
IEP: 通过表达模式推断
7057182 RGD
involved in dihydrofolate metabolic process IDA
IDA: 通过直接分析推断
8948466 RGD
involved in tetrahydrofolate biosynthetic process IDA
IDA: 通过直接分析推断
7057182 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

bifunctional purine biosynthesis protein ATIC

AICAR transformylase/inosine monophosphate cyclohydrolase

bifunctional purine biosynthesis protein PURH

bifunctional purine biosynthesis protein PURH-like

ATIC 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Atic O35567 P15127-PRO_0000016698 Rattus norvegicus P15127-PRO_0000016698
Anti Bait CoIP
25687571
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-N0485 Liensinine Diperchlorate Inhibitor 99.97% Phase 2
HY-135238 (rel)-RSD 921 Agonist / Phase 2
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P990067 Evunzekibart Inhibitor 97.02% Phase 1
Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-150252A ATIC-IN-1 acetate Inhibitor 99.96% 否
HY-N1448 Vincetoxicoside B Inhibitor 99.70% 否
HY-29244 ATIC-IN-2 Inhibitor ≥98.0% 否
HY-150252 ATIC-IN-1 99.69% 否
HY-E70121 Succinyl-CoA synthetase / 否
HY-141324 Tetraethyl butane-​1,​4-​diylbis(phosphoramid​ate) / 否
HY-RS01126 ATE1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS01156 ATIC Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17124 Atic Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23569 Atic Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens ATIC NCBI NCBI:471
Canis lupus familiaris ATIC NCBI
Mus musculus ATIC NCBI NCBI:108147
Macaca mulatta ATIC NCBI NCBI:694819
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