2. Gene
  3. Dpyd - dihydropyrimidine dehydrogenase Gene

Dpyd - dihydropyrimidine dehydrogenase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 81656 | 基因类型: protein coding

关于 Dpyd

功能概要

Enables several functions, including nucleotide binding activity; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; and protein homodimerization activity. Involved in several processes, including pyrimidine nucleobase metabolic process; response to glucocorticoid; and response to nutrient. Located in cytosol. Used to study colorectal Cancer. Biomarker of liver disease. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and pancreatic Cancer. Orthologous to human DPYD (dihydropyrimidine dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

Dpyd 基因产物(1)

mRNA Protein Name
NM_031027.2 NP_112289.2 dihydropyrimidine dehydrogenase [NADP(+)]
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables FAD binding IDA
IDA: 通过直接分析推断
7451435 RGD
enables NADP binding IDA
IDA: 通过直接分析推断
7626590 RGD
enables dihydropyrimidine dehydrogenase (NADP+) activity IDA
IDA: 通过直接分析推断
1544906 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
7451435 RGD
enables iron ion binding IDA
IDA: 通过直接分析推断
7451435 RGD
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
8373446 RGD
enables uracil binding IDA
IDA: 通过直接分析推断
7626590 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in circadian rhythm IDA
IDA: 通过直接分析推断
3202908 RGD
involved in circadian rhythm IEP
IEP: 通过表达模式推断
19628084 RGD
involved in pyrimidine nucleobase catabolic process IDA
IDA: 通过直接分析推断
1629785 RGD
involved in response to glucocorticoid IEP
IEP: 通过表达模式推断
9819714 RGD
involved in response to nutrient IDA
IDA: 通过直接分析推断
8252488 RGD
involved in response to organic cyclic compound IDA
IDA: 通过直接分析推断
9893640 RGD
involved in response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
8161345 RGD
involved in uracil metabolic process IDA
IDA: 通过直接分析推断
7626590 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
9348115 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

dihydropyrimidine dehydrogenase [NADP(+)]

DHPDHase

DPD

dihydrothymine dehydrogenase

dihydrouracil dehydrogenase

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-17469 Gimeracil Inhibitor 99.72% 否
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03979 DPYD Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W777340 Gimeracil-13C3 / 否
HY-17469S Gimeracil-13C3,15N / 否
HY-RS21328 Dpyd Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27847 Dpyd Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dpyd NCBI NCBI:1806
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