2. Gene
  3. Cyp8b1 - cytochrome P450 family 8 subfamily B member 1 Gene

Cyp8b1 - cytochrome P450 family 8 subfamily B member 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 81924 | 基因类型: protein coding

关于 Cyp8b1

功能概要

Enables sterol 12-alpha-hydroxylase activity. Involved in bile acid signaling pathway; response to cholesterol; and response to nutrient levels. Predicted to be located in endoplasmic reticulum membrane. Biomarker of extrahepatic cholestasis; non-alcoholic fatty liver disease; and premature menopause. Orthologous to human CYP8B1 (Cytochrome P450 family 8 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp8b1 基因产物(1)

mRNA Protein Name
NM_031241.2 NP_112520.2 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables sterol 12-alpha-hydroxylase activity IDA
IDA: 通过直接分析推断
10393316 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in response to cholesterol IEP
IEP: 通过表达模式推断
25263431 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
25263431 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase

cytochrome P450, 8b1, sterol 12 alpha-hydrolase

cytochrome P450, family 8, subfamily b, polypeptide 1

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-113259 7α-Hydroxy-4-cholesten-3-one 99.60% 否
HY-113259S 7α-Hydroxy-4-cholesten-3-one-d7 ≥98.0% 否
HY-113259R 7α-Hydroxy-4-cholesten-3-one (Standard) / 否
HY-RS03489 CYP8B1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17779 Cyp8b1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24246 Cyp8b1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cyp8b1 NCBI NCBI:1582
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