2. Gene
  3. Dgat1 - diacylglycerol O-acyltransferase 1 Gene

Dgat1 - diacylglycerol O-acyltransferase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: ARAT; Dgat

基因 ID: 84497 | 基因类型: protein coding

关于 Dgat1

功能概要

Enables diacylglycerol O-acyltransferase activity; diacylglycerol binding activity; and fatty acid binding activity. Involved in several processes, including Insulin secretion; positive regulation of hepatic stellate cell activation; and regulation of lipid metabolic process. Located in intracellular membrane-bounded organelle and plasma membrane. Biomarker of chronic kidney disease and nephrotic syndrome. Human ortholog(s) of this gene implicated in cardiomyopathy and congenital diarrhea 7 with exudative enteropathy. Orthologous to human DGAT1 (diacylglycerol O-acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Dgat1 基因产物(1)

mRNA Protein Name
NM_053437.2 NP_445889.2 diacylglycerol O-acyltransferase 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables acyltransferase activity IMP
IMP: 通过突变表型推断
18768481 RGD
enables diacylglycerol O-acyltransferase activity IDA
IDA: 通过直接分析推断
12193544 RGD
enables diacylglycerol binding IDA
IDA: 通过直接分析推断
14596837 RGD
enables fatty acid binding IDA
IDA: 通过直接分析推断
14596837 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in glycerolipid metabolic process IDA
IDA: 通过直接分析推断
12193544 RGD
involved in insulin secretion IMP
IMP: 通过突变表型推断
12193544 RGD
involved in ketone body metabolic process IMP
IMP: 通过突变表型推断
23449193 RGD
involved in positive regulation of fatty acid oxidation IMP
IMP: 通过突变表型推断
23449193 RGD
involved in positive regulation of hepatic stellate cell activation IMP
IMP: 通过突变表型推断
18000880 RGD
involved in positive regulation of triglyceride biosynthetic process IMP
IMP: 通过突变表型推断
23449193 RGD
involved in regulation of eating behavior IMP
IMP: 通过突变表型推断
23449193 RGD
involved in regulation of intestinal lipid absorption IMP
IMP: 通过突变表型推断
18768481 RGD
involved in regulation of vitamin A metabolic process IMP
IMP: 通过突变表型推断
18000880 RGD
involved in response to human chorionic gonadotropin IEP
IEP: 通过表达模式推断
17032584 RGD
involved in triglyceride biosynthetic process IDA
IDA: 通过直接分析推断
14596837 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

diacylglycerol O-acyltransferase 1

acyl-CoA retinol O-fatty-acyltransferase

acyl-coenzyme A:diacylglycerol acyltransferase 1

diacylglycerol acyltransferase

diglyceride acyltransferase

retinol O-fatty-acyltransferase

相关产品

Clinical Phase
生物活性分子 (4)
目录号 产品名 作用方式
纯度 Phase
HY-16278 Pradigastat Inhibitor 98.88% Phase 3
HY-13009 PF-04620110 Inhibitor 99.60% Phase 1
HY-15497 AZD7687 Inhibitor 99.80% Phase 1
HY-123765 JTT-553 Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (20)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10038 A 922500 Inhibitor 99.33% 否
HY-32219 T863 Inhibitor 99.83% 否
HY-12425 DGAT1-IN-1 Inhibitor ≥98.0% 否
HY-141572 1,2-Dioleoyl-sn-glycerol 99.96% 否
HY-50861 AZD3988 Inhibitor 99.89% 否
HY-15197 ABT-046 Inhibitor 98.57% 否
HY-50670 DGAT-1 inhibitor 2 Inhibitor 95.70% 否
HY-16434 DGAT1-IN-3 Inhibitor 99.92% 否
HY-118386 H2-005 / 否
HY-16088 BAY 74-4113 Inhibitor / 否
HY-16278A Pradigastat sodium Inhibitor / 否
HY-N7281 Aphadilactone C Inhibitor / 否
HY-RS03710 DGAT1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-136707 DGAT-1 inhibitor 3 Inhibitor / 否
HY-16266 JNJ-DGAT1-A Inhibitor / 否
HY-N9153A Guaiacylglycerol-8-O-4'-(sinapyl alcohol) ether / 否
HY-RS16667 Dgat1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23102 Dgat1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-111417 GSK2973980A Inhibitor / 否
HY-112851 Diacylglycerol acyltransferase inhibitor-1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dgat1 NCBI NCBI:8694
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