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  2. GALR3 - galanin receptor 3 Gene

GALR3 - galanin receptor 3 Gene

中文名称:甘丙肽受体 3

种属: Homo sapiens

基因 ID: 8484 | 基因类型: protein coding

关于 GALR3

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,823,382-37,825,485 (from NCBI)

This gene has 1 transcript (splice variant), 97 orthologues and 16 paralogues. Low expression observed in reference dataset.

功能概要

神经肽甘丙肽调节多种生理过程,包括认知/记忆、感觉/疼痛处理、激素分泌和进食行为。人类甘丙肽受体是 G 蛋白偶联受体,通过不同的信号通路在功能上与其细胞内效应器偶联。 GALR3 存在于许多组织中,可表达为 1.4、2.4 和 5 kb 的转录本[RefSeq 提供,2008 年 7 月]

The neuropeptide Galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human Galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts [provided by RefSeq, Jul 2008]

GALR3 基因产物(1)

mRNA Protein Name
NM_003614.2 NP_003605.1 galanin receptor type 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables galanin receptor activity IDA
IDA: 通过直接分析推断
9832121 GOA
enables peptide hormone binding IDA
IDA: 通过直接分析推断
24517231 GOA
enables peptide hormone binding IPI
IPI: 通过物理相互作用推断
9832121 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IDA
IDA: 通过直接分析推断
9832121 GOA
involved in galanin-activated signaling pathway IDA
IDA: 通过直接分析推断
9832121 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
24517231 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cilium IDA
IDA: 通过直接分析推断
28154160 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GALR3 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (34 - 291)

  • 0
  • 100
  • 200
  • 300
  • 368 a.a.
蛋白主名 其他名称

galanin receptor type 3

GAL3-R

关联疾病

疾病名称 别名
Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus GALR3 RGD RGD:2658
Bos taurus GALR3 VGNC VGNC:29241
Macaca mulatta GALR3 VGNC VGNC:107792
Canis familiaris GALR3 VGNC VGNC:41102
Mus musculus GALR3 MGD MGI:1329003