2. Gene
  3. ARHGAP19 - Rho GTPase activating protein 19 Gene

ARHGAP19 - Rho GTPase activating protein 19 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Rho GTP 酶激活蛋白 19

种属: Homo sapiens

基因 ID: 84986 | 基因类型: protein coding

关于 ARHGAP19

Cytogenetic location: 10q24.1 Genomic coordinates (GRCh38): 10:97,222,179-97,292,637 (from NCBI)

This gene has 7 transcripts (splice variants), 251 orthologues and 3 paralogues. Broad expression in testis (RPKM 13.6), bone marrow (RPKM 8.1) and 24 other tissues.

功能概要

ARHGAP 家族的成员，例如 ARHGAP19，编码 Rho GTP 酶的负调节因子 (参见 RHOA；MIM 165390) ，它们参与细胞迁移、增殖和分化、肌动蛋白重塑和 G1 细胞周期进程 (Lv 等人， 2007 [PubMed 17454002]) .[OMIM 提供，2008 年 3 月]

Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390), which are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle progression (Lv et al., 2007 [PubMed 17454002]).[supplied by OMIM, Mar 2008]

ARHGAP19 基因产物(3)

mRNA Protein Name
NM_001204300.2 NP_001191229.1 rho GTPase-activating protein 19 isoform 2
NM_001256423.2 NP_001243352.1 rho GTPase-activating protein 19 isoform 3
NM_032900.6 NP_116289.4 rho GTPase-activating protein 19 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16713569 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARHGAP19 蛋白结构

RhoGAP

RhoGAP: RhoGAP domain (125 - 280)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 494 a.a.
蛋白主名 其他名称

rho GTPase-activating protein 19

putative RhoGAP protein

关联疾病

疾病名称 别名
Endometrial Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Endometrium

Adenosquamous Carcinoma Of The Endometrium

Endometrial Adenosquamous Cancer

Endometrial Adenosquamous Cell Carcinoma
Malignant Otitis Externa

Necrotising Otitis Externa

Pseudomonas Aeruginosa Osteomyelitis Of The Temporal Bone
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00919 ARHGAP19 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ARHGAP19 RGD RGD:1593044
Mus musculus ARHGAP19 MGD MGI:1918335
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