1. Gene
  2. IFITM1 - interferon induced transmembrane protein 1 Gene

IFITM1 - interferon induced transmembrane protein 1 Gene

中文名称:干扰素诱导的跨膜蛋白 1

种属: Homo sapiens

同用名: 9-27; CD225; IFI17; LEU13; DSPA2a

基因 ID: 8519 | 基因类型: protein coding

关于 IFITM1

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:314,040-315,272 (from NCBI)

This gene has 29 transcripts (splice variants), 260 orthologues and 4 paralogues. Ubiquitous expression in spleen (RPKM 191.9), endometrium (RPKM 153.8) and 24 other tissues.

功能概要

干扰素诱导的跨膜 (IFITM) 蛋白是干扰素诱导的抗病毒蛋白家族。该家族包含五个成员,包括属于 CD225 超家族的 IFITM1、IFITM2 和 IFITM3。该基因编码的蛋白质限制多种病毒病原体进入细胞,例如甲型流感病毒、埃博拉病毒和 Sars-CoV-2。[RefSeq 提供,2021 年 11 月]

Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced Antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 that belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]

IFITM1 基因产物(1)

mRNA Protein Name
NM_003641.5 NP_003632.4 interferon-induced transmembrane protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
2398277 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of cell migration IMP
IMP: 通过突变表型推断
20838853 GOA
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
20838853 GOA
involved in negative regulation of viral entry into host cell IDA
IDA: 通过直接分析推断
21253575 GOA
involved in negative regulation of viral genome replication IDA
IDA: 通过直接分析推断
21253575 GOA
involved in negative regulation of viral genome replication IMP
IMP: 通过突变表型推断
21976647 GOA
involved in positive regulation of osteoblast differentiation IMP
IMP: 通过突变表型推断
22634173 GOA
involved in response to interferon-alpha IDA
IDA: 通过直接分析推断
22479637 GOA
involved in response to interferon-beta IDA
IDA: 通过直接分析推断
21253575 GOA
involved in response to type II interferon IDA
IDA: 通过直接分析推断
21253575 GOA
involved in response to virus IDA
IDA: 通过直接分析推断
21253575 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in lysosomal membrane IDA
IDA: 通过直接分析推断
26354436 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
26354436 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
28246125 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

IFITM1 蛋白结构

CD225

CD225: Interferon-induced transmembrane protein (21 - 100)

  • 0
  • 100
  • 125 a.a.
蛋白主名 其他名称

interferon-induced transmembrane protein 1

dispanin subfamily A member 2a

IFITM1 抗体

目录号 产品名 应用 反应物种
HY-P83321 IFITM1 Antibody (YA3066) WB, IHC-F, IHC-P, ICC/IF, IP Human

关联疾病

疾病名称 别名
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified

West Nile Virus

West Nile Virus, Susceptibility To

Wnv

Wnv, Susceptibility To

West Nile Viral Infection

Encephalitis, West Nile Fever

West Nile Fever

Dengue Virus

Dengue Virus, Susceptibility To

Dengue Fever, Protection Against

Dengue Fever

Rift Valley Fever

Rfv - [Rift Valley Fever]

Hepatitis C Virus

Hepatitis C Virus, Susceptibility To

Hepatitis C Virus Infection, Response To Therapy Of

Hcv

Hcv, Susceptibility To

Hepatitis C Virus, Resistance To

Hepatitis C Virus, Response To Therapy Of

Resistance To Hepatitis C Virus

Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus

Inflammatory Bowel Disease 27

IBD27

Cervical Cancer

Cervical Cancer, Somatic

Neoplasm Of Uterine Cervix

Cervix Cancer

Uterine Cervical Neoplasm

Cervical Neoplasm

Cervix Uteri Cancer

Tumor Of The Cervix Uteri

CERCA

Uterine Cervical Cancer

Neoplasms Cervical

Uterine Cervical Neoplasms

Cervical Cancers

Cancer, Cervical, Somatic

Malignant Tumor Of Cervix

Cervix Carcinoma

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus IFITM1 MGD MGI:1915963
Rattus norvegicus IFITM1 RGD RGD:1307601