1. Gene
  2. UNC5C - unc-5 netrin receptor C Gene

UNC5C - unc-5 netrin receptor C Gene

中文名称:unc-5 netrin 受体 C

种属: Homo sapiens

同用名: UNC5H3

基因 ID: 8633 | 基因类型: protein coding

关于 UNC5C

Cytogenetic location: 4q22.3 Genomic coordinates (GRCh38): 4:95,162,504-95,548,973 (from NCBI)

This gene has 5 transcripts (splice variants), 277 orthologues and 4 paralogues. Broad expression in thyroid (RPKM 2.7), adrenal (RPKM 2.7) and 21 other tissues.

功能概要

该基因产物属于 netrin 受体的 UNC-5 家族。 Netrins 是在神经发育过程中指导轴突延伸和细胞迁移的分泌蛋白。它们是双功能蛋白,可作为某些细胞类型的引诱剂和其他细胞类型的排斥剂,这些相反的作用被认为是由两类受体介导的。 UNC-5 受体家族介导对 netrin 的驱避反应;它们是跨膜蛋白,在细胞外区域含有 2 个免疫球蛋白 (Ig) 样结构域和 2 个 I 型血小板反应蛋白基序。[RefSeq 提供,2008 年 7 月]

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for Others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008]

UNC5C 基因产物(1)

mRNA Protein Name
NM_003728.4 NP_003719.3 netrin receptor UNC5C precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22685302 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
27068745 GOA
enables tubulin binding IPI
IPI: 通过物理相互作用推断
28483977 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in dorsal root ganglion development IDA
IDA: 通过直接分析推断
28483977 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
25419706 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

UNC5C 蛋白结构

I-set

I-set: Immunoglobulin I-set domain (168 - 257)

TSP_1

TSP_1: Thrombospondin type 1 domain (264 - 310)

TSP_1

TSP_1: Thrombospondin type 1 domain (318 - 367)

ZU5

ZU5: ZU5 domain (529 - 629)

Death

Death: Death domain (850 - 926)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 931 a.a.
蛋白主名 其他名称

netrin receptor UNC5C

protein unc-5 homolog 3

UNC5C 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
UNC5C O95185 TUBB3 Homo sapiens Q13509 28483977
种属内
UNC5C O95185 TUBB3 Homo sapiens Q13509 28483977
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Immunodeficiency 43

Hypoproteinemia, Hypercatabolic

IMD43

Beta-2-Microglobulin Deficiency

B2m Deficiency

Hypercatabolic Hypoproteinemia

Glass Syndrome

Chromosome 2q32-Q33 Deletion Syndrome

Satb2-Associated Syndrome

2q33.1 Microdeletion Syndrome

Sas

2q32-Q33 Microdeletion Syndrome

2q32q33 Microdeletion Syndrome

Monosomy 2q32

Monosomy 2q32-Q33

Monosomy 2q32q33

2q32 Deletion Syndrome

Del(2)(Q32)

Del(2)(Q32q33)

GLASS

2q32q33 Microdeletion Syndromes

Satb2 Syndrome

Satb2-Associated Syndrome Due To A Chromosomal Rearrangement

Del(2)(Q33.1)

Monosomy 2q33.1

Satb2-Associated Syndrome Due To A Pathogenic Variant

Satb2-Associated Syndrome Due To A Point Mutation

Satb2 Associated Disorder

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus UNC5C VGNC VGNC:66830
Macaca mulatta UNC5C VGNC VGNC:78723
Bos taurus UNC5C VGNC VGNC:36672
Mus musculus UNC5C MGD MGI:1095412
Rattus norvegicus UNC5C RGD RGD:735109
Canis familiaris UNC5C VGNC VGNC:48141