CCN4 - cellular communication network factor 4 Gene

中文名称：蜂窝通信网络因素 4

种属: Homo sapiens

同用名: WISP1; WISP1c; WISP1i; WISP1tc; WISP1-OT1; WISP1-UT1

基因 ID: 8840 | 基因类型: protein coding

关于 CCN4

Cytogenetic location: 8q24.22 Genomic coordinates (GRCh38): 8:133,191,039-133,231,690 (from NCBI)

This gene has 5 transcripts (splice variants), 230 orthologues and 5 paralogues. Broad expression in endometrium (RPKM 7.1), adrenal (RPKM 6.0) and 17 other tissues.

功能概要

该基因编码 Wnt1 诱导信号通路 (WISP) 蛋白亚家族的成员，属于结缔组织生长因子 (CTGF) 家族。 Wnt1 是富含半胱氨酸的糖基化信号蛋白家族的成员，可介导多种发育过程。 CTGF 家族成员的特征在于四个保守的富含半胱氨酸的结构域：胰岛素样生长因子结合结构域、von Willebrand 因子 C 型模块、血小板反应蛋白结构域和 C 末端胱氨酸结样结构域。该基因可能位于与恶性转化相关的 Wnt1 信号通路的下游。它在成纤维细胞中以高水平表达，并在结肠肿瘤中过表达。编码的蛋白质与核心蛋白聚糖和双糖链蛋白聚糖结合，这是存在于结缔组织细胞外基质中的富含亮氨酸的小蛋白聚糖家族的两个成员，并且可能阻止核心蛋白聚糖和双糖链蛋白聚糖在肿瘤细胞增殖中的抑制活性。它还通过激活 Akt 激酶减弱 p53 介导的细胞凋亡以响应 DNA 损伤。它在氨基酸水平上与小鼠蛋白有 83% 的相同性。已经鉴定出多个选择性剪接的转录本变体。[RefSeq 提供，2011 年 3 月]

This gene encodes a member of the Wnt1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. Wnt1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the Wnt1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated Apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]

CCN4 基因产物(4)

mRNA	Protein	Name
NM_001204869.2	NP_001191798.1	CCN family member 4 isoform 3 precursor
NM_001204870.2	NP_001191799.1	CCN family member 4 isoform 4 precursor
NM_003882.4	NP_003873.1	CCN family member 4 isoform 1 precursor
NM_080838.3	NP_543028.1	CCN family member 4 isoform 2 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	11598131	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of inflammatory response	IDA IDA: 通过直接分析推断	25281430	GOA
involved in positive regulation of osteoblast differentiation	IMP IMP: 通过突变表型推断	20684029	GOA
involved in regulation of cytokine production	IDA IDA: 通过直接分析推断	25281430	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	25281430	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCN4 蛋白结构

IGFBP

VWC

TSP_1

Cys_knot

0
100
200
300
367 a.a.

蛋白主名

其他名称

CCN family member 4

WISP1 3'UTR-associated RNA 1

CCN4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CCN4	O95388	OTX1	Homo sapiens	P32242	Validated Y2H	32296183
种属内	CCN4	O95388	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
种属内	CCN4	O95388	HOXA1	Homo sapiens	P49639	Validated Y2H	32296183
种属内	CCN4	O95388	HOXA1	Homo sapiens	P49639	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Bladder Transitional Cell Papilloma

Bladder Papilloma	Transitional Cell Papilloma Of Bladder
Urinary Bladder Urothelial Papilloma	Urothelial Papilloma
Bladder Urothelial Papilloma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis	Ipf
Fibrocystic Pulmonary Dysplasia	Pulmonary Fibrosis, Idiopathic
Pulmonary Fibrosis, Idiopathic, Susceptibility To	Cryptogenic Fibrosing Alveolitis
ILD2	Idiopathic Pulmonary Fibrosis, Familial
Fibrosing Alveolitis, Cryptogenic	Uip
Fibrosing Alveolitis	Interstitial Pneumonitis, Usual
Familial Idiopathic Pulmonary Fibrosis	Idiopathic Fibrosing Alveolitis, Chronic Form
Usual Interstitial Pneumonia	Fibrosing Alveolitis Cryptogenic
Hamman-Rich Disease	Idiopathic Pulmonary Fibrosis Familial
Interstitial Pneumonitis Usual	Fibrosis Idiopathic Pulmonary
Fibrosis, Pulmonary, Idiopathic	Hamman-Rich Syndrome
Chronic Idiopathic Pulmonary Fibrosis	Acute Interstitial Pneumonia
Interstitial Pulmonary Fibrosis	Ipf - [Idiopathic Pulmonary Fibrosis]
Idiopathic Lung Fibrosis	Fibrosing Lung Disease
Pulmonary Fibrosis Nos	Fibrosing Pneumonitis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02113	CCN4 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS17581	Ccn4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24041	Ccn4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	CCN4	VGNC	VGNC:36944
Macaca mulatta	CCN4	VGNC	VGNC:70706
Rattus norvegicus	CCN4	RGD	RGD:69431
Mus musculus	CCN4	MGD	MGI:1197008
Canis familiaris	CCN4	VGNC	VGNC:48414
Felis catus	CCN4	VGNC	VGNC:60547
Others	CCN4	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CCN4 - cellular communication network factor 4 Gene

关于 CCN4

功能概要

CCN4 基因产物(4)

CCN4 蛋白结构

CCN4 蛋白互作信息

关联疾病

直系同源

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CCN4 - cellular communication network factor 4 Gene

关于 CCN4

功能概要

CCN4 基因产物(4)

CCN4 蛋白结构

CCN4 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z