2. Gene
  3. ARHGAP11B - Rho GTPase activating protein 11B Gene

ARHGAP11B - Rho GTPase activating protein 11B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Rho GTP 酶激活蛋白 11B

种属: Homo sapiens

同用名: B'-T; FAM7B1; GAP (1-8)

基因 ID: 89839 | 基因类型: protein coding

关于 ARHGAP11B

Cytogenetic location: 15q13.2 Genomic coordinates (GRCh38): 15:30,626,128-30,649,229 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 244 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 7.6), lymph node (RPKM 4.9) and 16 other tissues.

功能概要

预测启用 GTPase 激活剂活动。参与大脑皮层发育和线粒体膜通透性的负调节。作用于对谷氨酰胺分解代谢过程产生积极影响的上游。位于线粒体基质中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable GTPase activator activity. Involved in cerebral cortex development and negative regulation of mitochondrial membrane permeability. Acts upstream of with a positive effect on glutamine catabolic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]

ARHGAP11B 基因产物(1)

mRNA Protein Name
NM_001039841.3 NP_001034930.1 inactive Rho GTPase-activating protein 11B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
NOT enables GTPase activator activity IDA
IDA: 通过直接分析推断
25721503 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
31883789 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cerebral cortex development IDA
IDA: 通过直接分析推断
25721503 GOA
acts upstream of positive effect glutamine catabolic process IDA
IDA: 通过直接分析推断
31883789 GOA
involved in negative regulation of mitochondrial membrane permeability IDA
IDA: 通过直接分析推断
31883789 GOA
NOT involved in positive regulation of GTPase activity IDA
IDA: 通过直接分析推断
27957544 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial matrix IDA
IDA: 通过直接分析推断
31883789 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARHGAP11B 蛋白结构

RhoGAP

RhoGAP: RhoGAP domain (66 - 209)

  • 0
  • 100
  • 200
  • 267 a.a.
蛋白主名 其他名称

inactive Rho GTPase-activating protein 11B

family with sequence similarity 7, member B1

关联疾病

疾病名称 别名
Chromosome 15q13.3 Deletion Syndrome

Chromosome 15q13.3 Microdeletion Syndrome

15q13.3 Microdeletion Syndrome

15q13.3 Microdeletion

Microdeletion 15q13.3 Syndrome

Del(15)(Q13.3)

Monosomy 15q13.3
Interstitial Nephritis, Karyomegalic

Karyomegalic Interstitial Nephritis

KMIN

Kin

Systemic Karyomegaly

Karyomegalic Tubulointerstitial Nephritis

Ktn
Benign Epilepsy With Centrotemporal Spikes

Rolandic Epilepsy

Benign Rolandic Epilepsy

Epilepsy, Rolandic

Bcects

Benign Childhood Epilepsy With Centrotemporal Spike

Sylvan Seizures

Becrs

Bects

Bre

Benign Epilepsy Of Childhood With Centrotemporal Spikes

Benign Familial Epilepsy Of Childhood With Rolandic Spikes

Centrotemporal Epilepsy
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00914 ARHGAP11B Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ARHGAP11B MGD MGI:2444300
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