2. Gene
  3. UCN2 - urocortin 2 Gene

UCN2 - urocortin 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：尿皮质素 2

种属: Homo sapiens

同用名: UR; SRP; URP; UCNI; UCN-II

基因 ID: 90226 | 基因类型: protein coding

关于 UCN2

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,561,718-48,563,781 (from NCBI)

This gene has 1 transcript (splice variant), 140 orthologues and 1 paralogue. Biased expression in skin (RPKM 5.7), endometrium (RPKM 1.2) and 4 other tissues.

功能概要

该基因是 sauvagine/促肾上腺皮质激素释放因子/urotensin I 家族的成员。它在结构上与促肾上腺皮质激素释放因子 (CRF) 基因相关，编码产物是 CRF 2 型受体的内源性配体。在大脑中，它可能是压力对食欲影响的原因。尽管基因家族名称相似，但该基因的产物与 urotensin II 没有序列相似性。[RefSeq 提供，2008 年 7 月]

This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]

UCN2 基因产物(1)

mRNA Protein Name
NM_033199.4 NP_149976.1 urocortin-2 preproprotein
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables corticotropin-releasing hormone receptor binding IPI
IPI: 通过物理相互作用推断
11329063 GOA
enables hormone binding IPI
IPI: 通过物理相互作用推断
11329063 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
11329063 GOA
involved in hormone-mediated signaling pathway IDA
IDA: 通过直接分析推断
11329063 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UCN2 蛋白结构

(72 - 109)

  • 0
  • 100
  • 112 a.a.
蛋白主名 其他名称

urocortin-2

prepro-urocortin 2

关联疾病

疾病名称 别名
Anxiety

Anxiety Disorder

Anxiety Disorders

Anxiety State

Anxieties

Anxiety Neurosis
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15408 UCN2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS15583 UTS2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20833 Uts2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27347 Uts2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus UCN2 VGNC VGNC:36638
Canis familiaris UCN2 VGNC VGNC:48109
Rattus norvegicus UCN2 RGD RGD:620765
Mus musculus UCN2 MGD MGI:2176375
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