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  2. PLXNA4 - plexin A4 Gene

PLXNA4 - plexin A4 Gene

中文名称:丛素 A4

种属: Homo sapiens

同用名: PLEXA4; PLXNA4A; PLXNA4B; FAYV2820; PRO34003

基因 ID: 91584 | 基因类型: protein coding

关于 PLXNA4

Cytogenetic location: 7q32.3 Genomic coordinates (GRCh38): 7:132,123,340-132,648,688 (from NCBI)

This gene has 5 transcripts (splice variants), 227 orthologues and 8 paralogues. Broad expression in fat (RPKM 7.3), brain (RPKM 3.4) and 14 other tissues.

功能概要

预测启用信号素受体活性。预计参与多个过程,包括轴突引导;轴突发生的正调控;和 GTPase 活性的调节。预计在几个过程的上游或内部起作用,包括神经系统发育;参与轴突引导的轴突延伸调节;和负趋化性的调节。预测位于质膜中。预计是信号素受体复合物的一部分。预计是质膜的组成部分。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable semaphorin receptor activity. Predicted to be involved in several processes, including axon guidance; positive regulation of axonogenesis; and regulation of GTPase activity. Predicted to act upstream of or within several processes, including nervous system development; regulation of axon extension involved in axon guidance; and regulation of negative chemotaxis. Predicted to be located in plasma membrane. Predicted to be part of semaphorin receptor complex. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PLXNA4 基因产物(4)

mRNA Protein Name
NM_001105543.2 NP_001099013.1 plexin-A4 isoform 3 precursor
NM_001393897.1 NP_001380826.1 plexin-A4 isoform 1 precursor
NM_020911.2 NP_065962.1 plexin-A4 isoform 1 precursor
NM_181775.4 NP_861440.2 plexin-A4 isoform 2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PLXNA4 蛋白结构

Sema

Sema: Sema domain (51 - 489)

PSI

PSI: Plexin repeat (509 - 558)

PSI

PSI: Plexin repeat (655 - 702)

PSI

PSI: Plexin repeat (804 - 855)

TIG

TIG: IPT/TIG domain (858 - 938)

TIG

TIG: IPT/TIG domain (955 - 1036)

TIG

TIG: IPT/TIG domain (1040 - 1138)

TIG

TIG: IPT/TIG domain (1156 - 1218)

Plexin_cytopl

Plexin_cytopl: Plexin cytoplasmic RasGAP domain (1311 - 1864)

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  • 1894 a.a.
蛋白主名 其他名称

plexin-A4

epididymis secretory sperm binding protein

关联疾病

疾病名称 别名
Hypogonadotropic Hypogonadism 16 With Or Without Anosmia

HH16

Hypogonadism, Hypogonadotropic, Type 16 With/Without Anosmia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus PLXNA4 VGNC VGNC:33060
Rattus norvegicus PLXNA4 RGD RGD:1308074
Macaca mulatta PLXNA4 VGNC VGNC:76186
Canis familiaris PLXNA4 VGNC VGNC:44721
Mus musculus PLXNA4 MGD MGI:2179061
Felis catus PLXNA4 VGNC VGNC:68917