2. Gene
  3. ARRDC4 - arrestin domain containing 4 Gene

ARRDC4 - arrestin domain containing 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含抑制域 4

种属: Homo sapiens

基因 ID: 91947 | 基因类型: protein coding

关于 ARRDC4

Cytogenetic location: 15q26.2 Genomic coordinates (GRCh38): 15:97,960,703-97,973,833 (from NCBI)

This gene has 1 transcript (splice variant), 165 orthologues and 5 paralogues. Ubiquitous expression in skin (RPKM 18.0), colon (RPKM 14.4) and 25 other tissues.

功能概要

预测启用泛素连接酶-底物适配器活动。在泛素蛋白转移酶活性的正调控上游或正调控中起作用。位于核内体和质膜。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable ubiquitin ligase-substrate adaptor activity. Acts upstream of or within positive regulation of ubiquitin-protein transferase activity. Located in endosome and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARRDC4 基因产物(1)

mRNA Protein Name
NM_183376.3 NP_899232.2 arrestin domain-containing protein 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
23236378 GOA
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: 通过直接分析推断
28594402 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of interferon-beta production IDA
IDA: 通过直接分析推断
28594402 GOA
acts upstream of or within positive regulation of ubiquitin-protein transferase activity IPI
IPI: 通过物理相互作用推断
23236378 GOA
involved in protein K63-linked ubiquitination IDA
IDA: 通过直接分析推断
28594402 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endosome IDA
IDA: 通过直接分析推断
23236378 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
23236378 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARRDC4 蛋白结构

Arrestin_N

Arrestin_N: Arrestin (or S-antigen), N-terminal domain (24 - 169)

Arrestin_C

Arrestin_C: Arrestin (or S-antigen), C-terminal domain (192 - 317)

  • 0
  • 100
  • 200
  • 300
  • 418 a.a.
蛋白主名 其他名称

arrestin domain-containing protein 4

ARRDC4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ARRDC4 Q8NCT1 AVPR2 Homo sapiens P30518
Anti Tag CoIP
23236378
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ulna And Fibula, Absence Of, With Severe Limb Deficiency

Schinzel Phocomelia Syndrome

Aarrs

Limb/Pelvis-Hypoplasia/Aplasia Syndrome

LPHAS

Schinzel Type Phocomelia

Absence Of Ulna And Fibula With Severe Limb Deficiency

Al-Awadi/Raas-Rothschild Syndrome

Al Awadi-Raas-Rothschild Syndrome

Al-Awadi/Raas-Rothschild/Schinzel Phocomelia Syndrome

Aplasia/Hypoplasia Of Limbs And Pelvis

Congenital Absence Of Ulna And Fibula

Severe Limb Deficit

Phocomelia, Schinzel Type

Al-Awadi-Raas-Rothschild Syndrome

Ulna And Fibula Absence Of With Severe Limb Deficiency

Limb Pelvis Hypoplasia Aplasia Syndrome

Limb/Pelvis/Uterus-Hypoplasia/Aplasia Syndrome

Ulna And Fibula, Absence Of, With Sever Limb Deficiency
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-122682 SBI-993 98.67% 否
HY-124418 SBI-477 Inhibitor ≥98.0% 否
HY-RS01033 ARRDC4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19500 Arrdc4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25994 Arrdc4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ARRDC4 VGNC VGNC:107995
Rattus norvegicus ARRDC4 RGD RGD:1311763
Canis familiaris ARRDC4 VGNC VGNC:38141
Mus musculus ARRDC4 MGD MGI:1913662
Bos taurus ARRDC4 VGNC VGNC:26174
Felis catus ARRDC4 VGNC VGNC:59946
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