2. Gene
  3. ENTPD6 - ectonucleoside triphosphate diphosphohydrolase 6 Gene

ENTPD6 - ectonucleoside triphosphate diphosphohydrolase 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：外核苷三磷酸二磷酸水解酶 6

种属: Homo sapiens

同用名: CD39L2; IL6ST2; IL-6SAG; NTPDase-6; dJ738P15.3

基因 ID: 955 | 基因类型: protein coding

关于 ENTPD6

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:25,195,712-25,228,075 (from NCBI)

This gene has 18 transcripts (splice variants), 204 orthologues and 7 paralogues. Ubiquitous expression in prostate (RPKM 15.7), colon (RPKM 15.3) and 25 other tissues.

功能概要

ENTPD6 类似于 E 型核苷酸酶 (NTPases) 。 NTP 酶，如 CD39，介导细胞外核苷酸的分解代谢。 ENTPD6 包含 4 个腺苷三磷酸双磷酸酶保守区域，这些区域是 NTP 酶的特征。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2015 年 12 月]

ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which are characteristic of NTPases. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

ENTPD6 基因产物(24)

mRNA Protein Name
NM_001114089.4 NP_001107561.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 2
NM_001247.5 NP_001238.3 ectonucleoside triphosphate diphosphohydrolase 6 isoform 1
NM_001317941.3 NP_001304870.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 3
NM_001322378.2 NP_001309307.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 1
NM_001322379.2 NP_001309308.1 ectonucleoside triphosphate diphosphohydrolase 6 isoform 4
NM_001322380.2 NP_001309309.1 ectonucleoside triphosphate diphosphohydrolase 6 isoform 5
NM_001322381.2 NP_001309310.1 ectonucleoside triphosphate diphosphohydrolase 6 isoform 5
NM_001322382.2 NP_001309311.1 ectonucleoside triphosphate diphosphohydrolase 6 isoform 6
NM_001322383.2 NP_001309312.1 ectonucleoside triphosphate diphosphohydrolase 6 isoform 6
NM_001322384.2 NP_001309313.1 ectonucleoside triphosphate diphosphohydrolase 6 isoform 6
NM_001322385.2 NP_001309314.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 7
NM_001322386.2 NP_001309315.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 8
NM_001322387.2 NP_001309316.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 9
NM_001322388.2 NP_001309317.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 10
NM_001322389.2 NP_001309318.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 11
NM_001322390.2 NP_001309319.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 12
NM_001322391.2 NP_001309320.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 12
NM_001322392.2 NP_001309321.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 13
NM_001322393.2 NP_001309322.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 14
NM_001322394.2 NP_001309323.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 15
NM_001322395.2 NP_001309324.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 16
NM_001322396.2 NP_001309325.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 17
NM_001322397.2 NP_001309326.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 18
NM_001322398.2 NP_001309327.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 19
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables CDP phosphatase activity IDA
IDA: 通过直接分析推断
14529283 GOA
enables GDP phosphatase activity IDA
IDA: 通过直接分析推断
14529283 GOA
enables IDP phosphatase activity IDA
IDA: 通过直接分析推断
14529283 GOA
enables UDP phosphatase activity IDA
IDA: 通过直接分析推断
14529283 GOA
enables nucleoside diphosphate phosphatase activity IDA
IDA: 通过直接分析推断
14529283 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular region IDA
IDA: 通过直接分析推断
11041856 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
11041856 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ENTPD6 蛋白结构

GDA1_CD39

GDA1_CD39: GDA1/CD39 (nucleoside phosphatase) family (99 - 480)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 484 a.a.
蛋白主名 其他名称

ectonucleoside triphosphate diphosphohydrolase 6

CD39 antigen-like 2

关联疾病

疾病名称 别名
Malignant Essential Hypertension

Accelerated Essential Hypertension
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04400 ENTPD6 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ENTPD6 RGD RGD:619725
Macaca mulatta ENTPD6 VGNC VGNC:72227
Felis catus ENTPD6 VGNC VGNC:61882
Mus musculus ENTPD6 MGD MGI:1202295
Bos taurus ENTPD6 VGNC VGNC:58980
Canis familiaris ENTPD6 VGNC VGNC:52876
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