2. Gene
  3. KIF20B - kinesin family member 20B Gene

KIF20B - kinesin family member 20B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：驱动蛋白家族成员 20B

种属: Homo sapiens

同用名: CT90; MPP1; KRMP1; MPP-1; MPHOSPH1

基因 ID: 9585 | 基因类型: protein coding

关于 KIF20B

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:89,701,590-89,774,934 (from NCBI)

This gene has 4 transcripts (splice variants) and 269 orthologues. Broad expression in testis (RPKM 5.3), lymph node (RPKM 5.3) and 24 other tissues.

功能概要

启用多项功能，包括 WW 域绑定活动；加端定向微管运动；和蛋白质同二聚化活性。参与细胞群增殖的正调节和胞质分裂的正调节。位于多种细胞成分中，包括微管细胞骨架；中体;和核腔。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including WW domain binding activity; plus-end-directed microtubule motor activity; and protein homodimerization activity. Involved in positive regulation of cell population proliferation and positive regulation of cytokinesis. Located in several cellular components, including microtubule cytoskeleton; midbody; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

KIF20B 基因产物(3)

mRNA Protein Name
NM_001284259.2 NP_001271188.1 kinesin-like protein KIF20B isoform 1
NM_001382506.1 NP_001369435.1 kinesin-like protein KIF20B isoform 3
NM_016195.4 NP_057279.2 kinesin-like protein KIF20B isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP hydrolysis activity IDA
IDA: 通过直接分析推断
11470801 GOA
enables WW domain binding IPI
IPI: 通过物理相互作用推断
11470801 GOA
enables microtubule binding IDA
IDA: 通过直接分析推断
12740395 GOA
enables plus-end-directed microtubule motor activity IDA
IDA: 通过直接分析推断
12740395 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17409436 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
11470801 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
12740395 GOA
involved in positive regulation of cytokinesis IMP
IMP: 通过突变表型推断
12740395 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
11470801 GOA
located in contractile ring IDA
IDA: 通过直接分析推断
17409436 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
8885239 GOA
located in midbody IDA
IDA: 通过直接分析推断
12740395 GOA
located in mitotic spindle midzone IDA
IDA: 通过直接分析推断
12740395 GOA
located in mitotic spindle pole IDA
IDA: 通过直接分析推断
11470801 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
11470801 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
11470801 GOA
located in nucleus IDA
IDA: 通过直接分析推断
12740395 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KIF20B 蛋白结构

Kinesin

Kinesin: Kinesin motor domain (64 - 479)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1820 a.a.
蛋白主名 其他名称

kinesin-like protein KIF20B

M-phase phosphoprotein 1

关联疾病

疾病名称 别名
Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder
Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07273 KIF20B Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus KIF20B MGD MGI:2444576
Canis familiaris KIF20B VGNC VGNC:42395
Rattus norvegicus KIF20B RGD RGD:1308497
Bos taurus KIF20B VGNC VGNC:107297
Macaca mulatta KIF20B VGNC VGNC:74035
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