1. Gene
  2. ZNF536 - zinc finger protein 536 Gene

ZNF536 - zinc finger protein 536 Gene

中文名称:锌指蛋白 536

种属: Homo sapiens

基因 ID: 9745 | 基因类型: protein coding

关于 ZNF536

Cytogenetic location: 19q12 Genomic coordinates (GRCh38): 19:30,225,592-30,713,586 (from NCBI)

This gene has 14 transcripts (splice variants), 258 orthologues and 14 paralogues. Biased expression in brain (RPKM 2.6), thyroid (RPKM 0.8) and 11 other tissues.

功能概要

该基因编码的蛋白质是高度保守的锌指蛋白。编码的蛋白质在大脑中最为丰富,它负向调节神经元分化。[RefSeq 提供,2015 年 9 月]

The protein encoded by this gene is a highly conserved Zinc Finger Protein. The encoded protein is most abundant in brain, where it negatively regulates neuronal differentiation. [provided by RefSeq, Sep 2015]

ZNF536 基因产物(4)

mRNA Protein Name
NM_001352260.2 NP_001339189.1 zinc finger protein 536 isoform 2
NM_001376110.1 NP_001363039.1 zinc finger protein 536 isoform 3
NM_001376111.1 NP_001363040.1 zinc finger protein 536 isoform 3
NM_014717.3 NP_055532.1 zinc finger protein 536 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
19398580 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
19398580 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
19398580 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ZNF536 蛋白结构

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (145 - 166)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (274 - 297)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (300 - 323)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (345 - 367)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (373 - 395)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (632 - 653)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (765 - 788)

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  • 1300 a.a.
蛋白主名 其他名称

zinc finger protein 536

直系同源

种属 基因名 来源 基因 ID
Mus musculus ZNF536 MGD MGI:1926102
Rattus norvegicus ZNF536 RGD RGD:1563363
Bos taurus ZNF536 VGNC VGNC:37299
Canis familiaris ZNF536 VGNC VGNC:48756
Felis catus ZNF536 VGNC VGNC:67325