Glatiramer acetate 

Glatiramer acetate, a synthetic analogue of myelin basic protein and an immunomodulating agent, inhibits Experimental autoimmune encephalomyelitis (EAE), and can be used for the research of multiple sclerosis. Glatiramer acetate exhibits strong and promiscuous binding to MHC molecules and consequent competition with various myelin antigens for their presentation to T cells. A further aspect of its action is potent induction of specific suppressor cells of the T helper 2 (Th2) type that migrate to the brain and lead to in situ bystander suppression^[1][2][3].

Glatiramer (25-100 mg/kg；皮下注射；5 天) acetate 可提高脑源性神经营养因子 (BDNF)水平^[3]。
在亨廷顿舞蹈症 (HD) 小鼠模型中，N171-82Q 转基因小鼠表现出更快速的病程进展。Glatiramer (1 mg/只小鼠；皮下注射；每周 5 次) acetate 从 8 周龄开始给药，持续至 20 周龄，接近因疾病死亡的年龄。Glatiramer acetate 可改善多项运动功能指标。在 4 天内进行的转棒测试中，Glatiramer acetate 显著提高了 15 周龄 N171-82Q 转基因小鼠的表现^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(C₉H₁₁NO₃.C₆H₁₄N₂O₂.C₅H₉NO₄.C₃H₇NO₂)x.xC₂H₄O₂

147245-92-9

固体

Off-white to light yellow

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Lalive PH, et al. Glatiramer acetate in the treatment of multiple sclerosis: emerging concepts regarding its mechanism of action. CNS Drugs. 2011 May;25(5):401-14.  [Content Brief]

  [2]. McKeage K. Glatiramer Acetate 40 mg/mL in Relapsing-Remitting Multiple Sclerosis: A Review. CNS Drugs. 2015;29(5):425-432.  [Content Brief]

  [3]. Arnon R, et al. Mechanism of action of glatiramer acetate in multiple sclerosis and its potential for the development of new applications. Proc Natl Acad Sci U S A. 2004;101 Suppl 2(Suppl 2):14593-14598.  [Content Brief]

  [4]. Corey-Bloom J, et al. Beneficial effects of glatiramer acetate in Huntington's disease mouse models: Evidence for BDNF-elevating and immunomodulatory mechanisms. Brain Res. 2017;1673:102-110.  [Content Brief]

  [5]. Aharoni R, et al. Glatiramer acetate-specific T cells in the brain express T helper 2/3 cytokines and brain-derived neurotrophic factor in situ [published correction appears in Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12288]. Proc Natl Acad Sci U S A. 2003;100(24):14157-14162.  [Content Brief]