1. Immunology/Inflammation
  2. Interleukin Related
  3. HB-0017

HB-0017 是一种靶向 IL-17A 的人源化 IgG1κ 单克隆抗体抑制剂,。HB-0017 可以抑制 IL-17A 诱导的 IL-6 分泌,其 IC50 为 2.09 nM。HB-0017 显著减少 Imiquimod (HY-B0180) 诱发的银屑病样小鼠模型中的耳廓厚度,并缓解 IL-17A 诱导的关节炎和气囊小鼠模型中的炎症。HB-0017的同型对照可参考 Human IgG1 kappa, Isotype Control (HY-P99001)。

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HB-0017 Chemical Structure

HB-0017 Chemical Structure

CAS No. : 2790610-50-1

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  • 生物活性

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生物活性

HB-0017 is a humanized IgG1κ monoclonal antibody inhibitor, targeting IL-17A. HB-0017 inhibits the IL-6 secretion induced by IL-17A with an IC50 of 2.09 nM. HB-0017 significantly decreases ear thickness in Imiquimod (HY-B0180)-induced psoriasis-like mice model and alleviates inflammations in IL-17A-induced arthritis and air pouch mice model. The isotype control for the HB-0017 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001)[1].

IC50 & Target[1]

IL-17A

 

基因 ID

3605  [NCBI]

Accession
靶点

IL-17A

应用

ELISA, FACS, Functional assay

偶联物

Unconjugated

复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.

CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
HB-0017
目录号:
HY-P991595
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