2. Apoptosis Cell Cycle/DNA Damage Epigenetics
  3. Apoptosis HDAC
  4. HDAC-IN-27 dihydrochloride

HDAC-IN-27 dihydrochloride (Compound 11h) 是一种有效的、具有口服活性的 HDAC I 类选择性抑制剂，对 HDAC1-3 的 IC50 值范围为 0.43 至 3.01 nM。HDAC-IN-27 dihydrochloride 还具有体内和体外抗癌活性。HDAC-IN-27 对急性髓系白血病 (AML) 细胞系表现出显著的抗增殖活性，并通过诱导细胞凋亡 (apoptosis) 和组蛋白乙酰化 (AcHH3 和 AcHH4) 发挥作用。HDAC-IN-27 dihydrochloride 可以用于急性髓系白血病 (AML) 的研究。

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HDAC-IN-27 dihydrochloride Chemical Structure

HDAC-IN-27 dihydrochloride Chemical Structure

CAS No. : 3069831-25-7

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Other Forms of HDAC-IN-27 dihydrochloride:

HDAC-IN-27 dihydrochloride 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC-IN-27 dihydrochloride (Compound 11h) is a potent, orally active class I HDAC-selective inhibitor with IC50 values ranging from 0.43 to 3.01 nM against HDAC1-3. HDAC-IN-27 dihydrochloride exhibits both in vivo and in vitro antitumor activity. HDAC-IN-27 dihydrochloride demonstrates significant anti-proliferative activity against acute myeloid leukemia (AML) cell lines by inducing apoptosis and histone acetylation (AcHH3 and AcHH4). HDAC-IN-27 dihydrochloride can be used for research in acute myeloid leukemia (AML)[1].

IC50 & Target[1]

HDAC1

3.01 nM (IC50)

HDAC2

18.54 nM (IC50)

HDAC3

0.435 nM (IC50)

体外研究
(In Vitro)

在野生型 p53 的 MV4-11 细胞中，HDAC-IN-27 dihydrochloride (11h) 可导致 caspase-3 前体 (pro-caspase-3) 剪切、明显的凋亡性细胞死亡以及亚 G1 期细胞群体的积累；而在 HL60 细胞中则诱导 G2/M 期阻滞，未观察到明显的凋亡现象[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-27 dihydrochloride 相关抗体:
分子量

423.34

Formula

C20H24Cl2N4O2
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

HDAC-IN-27 dihydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-273069831-25-7ApoptosisHDACHistone deacetylasespro-caspase-3 cleavagecell deathHL60 cellsG2/M arrestacute myeloid leukemiaMV4-11apoptosisInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-142690A
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