2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. HDAC-IN-27

HDAC-IN-27 (Compound 11h) 是一种有效的、具有口服活性的 HDAC I 类选择性抑制剂，对 HDAC1-3 的 IC50 值范围为 0.43 至 3.01 nM。HDAC-IN-27 还具有体内和体外抗癌活性。HDAC-IN-27 对急性髓系白血病 (AML) 细胞系表现出显著的抗增殖活性，并通过诱导细胞凋亡 (apoptosis) 和组蛋白乙酰化 (AcHH3 和 AcHH4) 发挥作用。HDAC-IN-27 可以用于急性髓系白血病 (AML) 的研究。

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HDAC-IN-27 Chemical Structure

HDAC-IN-27 Chemical Structure

CAS No. : 2763368-89-2

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HDAC-IN-27 的其他形式现货产品:

Customer Review

Other Forms of HDAC-IN-27:

HDAC-IN-27 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC-IN-27 (Compound 11h) is a potent, orally active class I HDAC-selective inhibitor with IC50 values ranging from 0.43 to 3.01 nM against HDAC1-3. HDAC-IN-27 exhibits both in vivo and in vitro antitumor activity. HDAC-IN-27 demonstrates significant anti-proliferative activity against acute myeloid leukemia (AML) cell lines by inducing apoptosis and histone acetylation (AcHH3 and AcHH4). HDAC-IN-27 can be used for research in acute myeloid leukemia (AML)[1].

IC50 & Target[1]

HDAC1

3.01 nM (IC50)

HDAC2

18.54 nM (IC50)

HDAC3

0.435 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HL-60 IC50
26.21 nM
Compound: 11h
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability after 48 hrs by multiplate reader method
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability after 48 hrs by multiplate reader method
[PMID: 34942071]
MOLM-13 IC50
40.4 nM
Compound: 11h
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability measured after 48 hrs by multiplate reader method
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability measured after 48 hrs by multiplate reader method
[PMID: 34942071]
MV4-11 IC50
19.17 nM
Compound: 11h
Antiproliferative activity against human MV4-11 AML cells assessed as cell viability measured after 48 hrs by by multiplate reader method
Antiproliferative activity against human MV4-11 AML cells assessed as cell viability measured after 48 hrs by by multiplate reader method
[PMID: 34942071]
RS4-11 IC50
31.52 nM
Compound: 11h
Antiproliferative activity against human RS4-11 cells assessed as reduction in cell viability measured after 48 hrs by multiplate reader method
Antiproliferative activity against human RS4-11 cells assessed as reduction in cell viability measured after 48 hrs by multiplate reader method
[PMID: 34942071]
U-937 IC50
60.51 nM
Compound: 11h
Antiproliferative activity against human U-937 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human U-937 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 34942071]
体外研究
(In Vitro)

在野生型 p53 的 MV4-11 细胞中，HDAC-IN-27 dihydrochloride (11h) 可导致 caspase-3 前体 (pro-caspase-3) 剪切、明显的凋亡性细胞死亡以及亚 G1 期细胞群体的积累；而在 HL60 细胞中则诱导 G2/M 期阻滞，未观察到明显的凋亡现象[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-27 相关抗体:
分子量

350.41

Formula

C20H22N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC-IN-27 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-272763368-89-2HDACApoptosisHistone deacetylasespro-caspase-3 cleavagecell deathHL60 cellsG2/M arrestacute myeloid leukemiaMV4-11apoptosisInhibitorinhibitorinhibit

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