2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. HDAC-IN-42

HDAC-IN-42 (compound 14f) 是一种有效的选择性 HDAC 抑制剂，对 HDAC1 和 HDAC6 的 IC50 值分别为 0.19 和 4.98 µM。HDAC-IN-42 显示出抗癌和抗增殖活性。HDAC-IN-42 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G2/M 期。

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HDAC-IN-42 Chemical Structure

HDAC-IN-42 Chemical Structure

CAS No. : 2454024-18-9

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HDAC-IN-42 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC-IN-42 (compound 14f) is a potent and selective HDAC inhibitor with IC50 values of 0.19 and 4.98 µM for HDAC1 and HDAC6, respectively. HDAC-IN-42 shows anticancer and anti-proliferative activity. HDAC-IN-42 induces apoptosis and cell cycle arrest at G2/M phase[1].

IC50 & Target[1]

HDAC1

0.19 μM (IC50)

HDAC6

4.98 μM (IC50)

体外研究
(In Vitro)

HDAC-IN-42 (compound 14f) shows anti-proliferative activity with C50s of 9.56, 13.32, 10.46, 6.91 µM for MCF-7, HCT-116, HepG2, Hela cells, respectively[1].
HDAC-IN-42 (1, 5, 10 µM; 24 h) reduces the colony formation and increases the expression of histone H3 and α-tubulin in HeLa cells[1].
HDAC-IN-42 (1, 5, 10 µM; 48 h) induces apoptosis and cell cycle arrest at G2/M phase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-42 相关抗体:
分子量

381.34

Formula

C20H15NO7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC-IN-42 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-422454024-18-9HDACApoptosisHistone deacetylasesHeLa cellsapoptosisG2/M phaseanticanceranti-proliferativehistone H3α-tubulinInhibitorinhibitorinhibit

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产品名称：
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目录号：
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