2. PROTAC Epigenetics Cell Cycle/DNA Damage
  3. PROTACs Aurora Kinase
  4. HLB-0532259

HLB-0532259 是一种 PROTAC 降解剂，可降解 Aurora-A 和 N-Myc。HLB-0532259 可在非 MYCN 扩增的 MCF-7 中降解 Aurora-A，DC50 为 20.2 nM；可在 MYCN 扩增的细胞 SK-N-BE 和 Kelly 中降解 N-Myc，DC50 为 179 nM 和 229 nM。HLB-0532259 在小鼠模型中表现出抗肿瘤活性。(Pink: ligand for target protein (HY-168440); Black: linker (HY-W007957); Blue: ligand for E3 ligase Cereblon (HY-41547))

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HLB-0532259 Chemical Structure

HLB-0532259 Chemical Structure

CAS No. : 2566733-45-5

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规格 价格 是否有货 数量
1 mg ￥1440
5 - 7 周
5 mg ￥3600
5 - 7 周
10 mg ￥5800
5 - 7 周
50 mg   询价  
100 mg   询价  

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Customer Review

HLB-0532259 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 Aurora Kinase 亚型特异性产品:

查看所有亚型
Aurora Kinase Aurora A Aurora B Aurora C

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HLB-0532259 is a PROTAC degrader for Aurora-A and N-Myc. HLB-0532259 degrades Aurora-Ain a non-MYCN amplified MCF-7 with a DC50 of 20.2 nM, degrades N-Myc in MYCN amplified cells SK-N-BE and Kelly with DC50 of 179 nM and 229 nM. HLB-0532259 exhibits antitumor efficacy in mouse models[1]. (Pink: ligand for target protein (HY-168440); Black: linker (HY-W007957); Blue: ligand for E3 ligase Cereblon (HY-41547))

分子量

748.83

Formula

C40H44N8O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HLB-0532259 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HLB-05322592566733-45-5HLB0532259HLB 0532259PROTACsAurora KinaseCD-1 mouseMCF-7SK-N-BEKellyInhibitorinhibitorinhibit

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目录号：
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