2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Apoptosis
  3. RAR/RXR Apoptosis
  4. HX630

HX630 是一种有效的维甲酸 X 受体 (RXR) 激动剂，可以诱导细胞凋亡(apoptosis)，具有抗肿瘤作用，可用于库欣病研究。

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HX630 Chemical Structure

HX630 Chemical Structure

CAS No. : 188844-52-2

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规格 价格 是否有货 数量
5 mg ￥5796
3 - 4 周
10 mg ￥9269
3 - 4 周
50 mg   询价  
100 mg   询价  

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Customer Review

HX630 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HX630 is a potent retinoic acid X receptor (RXR) agonist, can induce apoptosis, has anti-tumor effect, and can be used in Cushing's disease research[1].

体外研究
(In Vitro)

HX630 (0.1-10 μM, 96 h) 可以剂量依赖性的抑制细胞增殖诱导 AtT20 细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HX630 相关抗体:

Cell Viability Assay[1]

Cell Line: AtT20 cells
Concentration: 0.1, 1, 5, 10 μM
Incubation Time: 96 h
Result: Significantly inhibited AtT20 cell proliferation at 10 μM.
Decreased Pomc mRNA expression and ACTH secretion in a dose-dependent manner.
体内研究
(In Vivo)

HX630（5 mg/kg，腹腔注射，每周 3 次，持续 3 周）在感染了AtT20 细胞的 BALB/c-nu 小鼠模型中，可以减少肿瘤的生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c-nu mice (nu/nu) with AtT20 cells[1]
Dosage: 5 mg/kg
Administration: i.p., 3 times a week for 3 weeks
Result: Significantly reduced tumor volume and Pomc mRNA expression in tumor cells, but body weight and plasma ACTH levels were not significantly different.
分子量

441.58

Formula

C28H27NO2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HX630 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HX630188844-52-2HX 630HX-630RAR/RXRApoptosisRetinoic acid receptorsRetinoid X receptorsretinoic acid X receptorapoptosisanti-tumorCushing's diseaseInhibitorinhibitorinhibit

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HY-108520
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