2. Antibody-drug Conjugate/ADC Related Immunology/Inflammation Cell Cycle/DNA Damage Apoptosis
  3. Antibody-Drug Conjugates (ADCs) CD22 DNA/RNA Synthesis Apoptosis
  4. Inotuzumab ozogamicin

Inotuzumab ozogamicin  (Synonyms: CMC-544; PF-5208773; WAY-207294)

目录号: HY-P9959
技术支持

Inotuzumab ozogamicin (CMC-544) 是一种抗 CD22 抗体-药物偶联物 (ADC)。Inotuzumab ozogamicin 由人源化 IgG4 抗 CD22 mAb 组成，通过对酸不稳定的 AcBut (HY-132261) 连接子与 Calicheamicin (HY-19609) 共价连接。其中抗体部分是 Inotuzumab (HY-P99264)，ADC 毒性分子和 linker 偶联物是 N-Ac-γ-Calicheamicin-AcBut-NHS ester (HY-103688)。Inotuzumab ozogamicin 与 DNA 小沟结合，诱导双链断裂，随后导致细胞凋亡 (apoptosis)。Inotuzumab ozogamicin 可用于复发或难治性 B 细胞前体急性淋巴细胞白血病 (ALL) 的研究。

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CAS No. : 635715-01-4

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Inotuzumab ozogamicin 相关抗体

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  • 生物活性

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生物活性

Inotuzumab ozogamicin (CMC-544) is an anti-CD22 antibody-drug conjugate (ADC). Inotuzumab ozogamicin consists of a humanized IgG4 anti-CD22 mAb, covalently linked to Calicheamicin (HY-19609) via an acid-labile AcBut (HY-132261) linker. The antibody portion is Inotuzumab (HY-P99264), and the drug-linker conjugate for ADC is N-Ac-γ-Calicheamicin-AcBut-NHS ester (HY-103688). Inotuzumab ozogamicin binds to the minor groove of DNA, inducing double-strand cleavage and subsequent apoptosis. Inotuzumab ozogamicin can be used for the study of relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL)[1].

Clinical Trial
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
同用名

CMC-544; PF-5208773; WAY-207294

CAS 号
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
纯度 & 产品资料
参考文献

Inotuzumab ozogamicin 相关分类

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Keywords:

Inotuzumab ozogamicin635715-01-4CMC-544 PF-5208773 WAY-207294CMC544CMC 544PF5208773PF 5208773PF-5208773WAY207294WAY 207294WAY-207294Antibody-Drug Conjugates (ADCs)CD22DNA/RNA SynthesisApoptosisAntibody-Drug ConjugatesSiglec 2Anti-CD22 ADCapoptosisdouble-strand cleavagerefractory B-cell precursor acute lymphoblastic leukemia (ALL)Inhibitorinhibitorinhibit

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