2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Intetumumab

Intetumumab  (Synonyms: CNTO 95; Anti-Human CD51 Recombinant Antibody)

目录号: HY-P99296 纯度: 99.24%
COA

摩尔计算器

Intetumumab (CNTO 95) 是一种有效的抗 EGFR 单克隆抗体，是糖工程增强抗体依赖性细胞毒性 (ADCC)。Intetumumab 可用于癌症的研究。

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Intetumumab Chemical Structure

Intetumumab Chemical Structure

CAS No. : 725735-28-4

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规格 价格 是否有货 数量
1 mg ￥3200
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Intetumumab 相关抗体

Top Publications Citing Use of Products

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Intetumumab (CNTO 95) is a potent anti-EGFR monoclonal antibody that is glycoengineered for enhanced antibody-dependent cellular cytotoxicity (ADCC). Intetumumab can be used in research of cancer[1][2].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Human
体外研究
(In Vitro)

Intetumumab (CNTO 95; 0-5 μg/mL; 20 min; USPC-ARK-3 cells) inhibits integrin-mediated USPC cell adherence to a vitronectin substratum and inhibits serum-induced migration of USPC cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Intetumumab 相关抗体:
体内研究
(In Vivo)

Intetumumab (CNTO 95; 10 mg/kg; i.p.; Male nude rats) inhibits tumor growth and inhibits spontaneous lung metastasis of A549 tumors and decreases both the number of rats with lung metastasis and the number of metastatic lesions per lung[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male nude rats with lung metastasis models (5-6 weeks old and 150-200 g)[2]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; once a week for 60 days
Result: Had the total tumor response rates (CR and PR) was 33% in A549 tumor model.
Developed lung metastases only 4 of 9 rats.
Clinical Trial
分子量

145.6 (kDa)

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Intetumumab 相关分类

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  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Intetumumab725735-28-4CNTO 95 Anti-Human CD51 Recombinant AntibodyCNTO95CNTO-95EGFREpidermal growth factor receptorErbB-1HER1monoclonal antibodycancerADCCInhibitorinhibitorinhibit

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