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  3. Itopride

Itopride  (Synonyms: HSR803 free base)

目录号: HY-B0732A
产品使用指南

Itopride (HSR803 free base) 是一种口服有效的多巴胺 2 (dopamine-2) 拮抗剂和乙酰胆碱酯酶 (AChE) 抑制剂。Itopride 通过抗多巴胺能和抗乙酰胆碱酯作用增强胃动力,可用作胃肠促动力剂。Itopride 可用于胃食管返流疾病 (GERD) 的研究。

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Itopride Chemical Structure

Itopride Chemical Structure

CAS No. : 122898-67-3

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Itopride 的其他形式现货产品:

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Other Forms of Itopride:

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Itopride (HSR803 free base) is a potent and orally active dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD)[1].

IC50 & Target[1]

AChE

 

D2 Receptor

 

体外研究
(In Vitro)

Itopride has prokinetic effects on both the ileum and colon, which are regulated through inhibitory effects on AChE and antagonistic effects on dopamine D2 receptor[3].
Itopride hydrochloride (0.1 nM-1 μM) significantly accelerats the propagation velocity of the peristalsis in ex guinea pig ileum[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Itopride (30 mg/kg; p.o.) significantly accelerates gastric emptying compared with the vehicle group[4].
Itopride (30 mg/kg; p.o.) displays Cmax of 358 ‰, T1/2 of 24.9 min[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

358.43

Formula

C20H26N2O4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Itopride
目录号:
HY-B0732A
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