2. Epigenetics Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt
  3. JAK
  4. JAK3-IN-17

JAK3-IN-17 (Compound X15) 是一种具有口服活性的 JAK3 抑制剂 (IC50: 14.56 nM)。JAK3-IN-17 在 DNCB 诱发的小鼠特应性皮炎模型中可抑制 IL-2 和 IL-6 的产生，具有抗炎活性。

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JAK3-IN-17 Chemical Structure

JAK3-IN-17 Chemical Structure

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JAK3-IN-17 相关抗体

Top Publications Citing Use of Products

查看 JAK 亚型特异性产品:

查看所有亚型
JAK1 JAK2 JAK3 Tyk2 JAK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JAK3-IN-17 (Compound X15) is an orally active JAK3 inhibitor (IC50: 14.56 nM). JAK3-IN-17 inhibits the production of IL-2 and IL-6 in a DNCB-induced mouse atopic dermatitis model and exhibits anti-inflammatory activity[1].

IC50 & Target[1]

JAK3

14.56 nM (IC50)

药代动力学
(Parmacokinetics)[1]
Species Dose Route Indicator value
Rat 2 mg/kg i.v. T1/2 2.68 hr
Rat 20 mg/kg p.o. T1/2 20.33 hr
Rat 2 mg/kg i.v. Tmax 0.75 hr
Rat 20 mg/kg p.o. Tmax 0.5 hr
Rat 2 mg/kg i.v. Cmax 53.13 ng/mL
Rat 20 mg/kg p.o. Cmax 29.7 ng/mL
Rat 2 mg/kg i.v. AUC0-t 0.1042 μg·h/mL
Rat 20 mg/kg p.o. AUC0-t 0.9504 μg·h/mL
Rat 2 mg/kg i.v. AUC0-∞ 0.1053 μg·h/mL
Rat 20 mg/kg p.o. AUC0-∞ 0.2884 μg·h/mL
Rat 2 mg/kg i.v. MRT0-t 1.66 hr
Rat 20 mg/kg p.o. MRT0-t 4.42 hr
Rat 2 mg/kg i.v. MRT0-∞ 190.8 hr
Rat 20 mg/kg p.o. MRT0-∞ 27.77 hr
Rat 2 mg/kg i.v. CL 19.56 L/h/kg
Rat 20 mg/kg p.o. CL 123.87 L/h/kg
Rat 2 mg/kg i.v. F 27.38 %
分子量

358.37

Formula

C21H15FN4O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JAK3-IN-17 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JAK3-IN-17JAKJanus kinaseAnti-inflammatoryIL-2IL-6atopic dermatitisBa/F3-TEL-JAK3 cellsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-173601
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