2. Anti-infection
  3. Bacterial
  4. JNJ-2901

JNJ-2901 是 M. tuberculosis cytochrome bc1:aa3 抑制剂。JNJ-2901 可降低 M. tuberculosis H37Rv-ΔcydAB 急性/慢性小鼠感染模型中的细菌载量。JNJ-2901 可用于结核病 (TB) 的研究。

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JNJ-2901 Chemical Structure

JNJ-2901 Chemical Structure

CAS No. : 2059985-55-4

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JNJ-2901 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JNJ-2901 is an inhibitor of M. tuberculosis cytochrome bc1:aa3. JNJ-2901 reduces bacterial load in the acute/chronic mouse infection models of M. tuberculosis H37Rv-ΔcydAB. JNJ-2901 can be used in tuberculosis (TB) research[1].

体外研究
(In Vitro)

JNJ-2901 (0.005 µM-5 mM，5 天) 可抑制在 7H9 培养基中 M. tuberculosis H37Rv-ΔcydAB 的生长 (MIC50: 2.5 nM)[1]。
JNJ-2901 抑制 M. smegmatis 野生型菌株 (IC50: 89 nM) 和细胞色素 bd 敲除菌株(ΔcydAB) (IC50: 60 nM) 的氧消耗，但对细胞色素 bc 敲除菌株 (ΔqcrCAB) 无明显作用[1]。
JNJ-2901 抑制 M. smegmatis 细胞色素 bcMtb-like 的氧消耗 (IC50: 17.4 nM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JNJ-2901 相关抗体:
体内研究
(In Vivo)

JNJ-2901 (10 mg/kg，皮下注射，12 天/8 周) 可减少 M. tuberculosis H37Rv-ΔcydAB 急性/慢性小鼠感染模型中 6-8 周龄雌性 Balb/cBy 小鼠的细菌载量 (3.6-log/4.0-log)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Acute/chronic mouse model infected with M. tuberculosis H37Rv-ΔcydAB, 6-8 weeks old female Balb/cBy mice[1].
Dosage: 10 mg/kg
Administration: Subcutaneous injection (s.c.), 12 d for acute infection and 8 weeks for chronic infection
Result: Reduced bacterial load in an acute infection model in mice (3.6-log) and in a chronic infection model (4.0-log).
分子量

540.99

Formula

C24H24ClF3N4O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JNJ-2901 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-29012059985-55-4JNJ2901JNJ 2901BacterialAnti-bacterialM. tuberculosisM. smegmatisM. tuberculosis mouse infection modelTBInhibitorinhibitorinhibit

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