KD6001

目录号: HY-P991566: Data Sheet
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KD6001 是一种人源化 IgG1κ 单克隆抗体，靶向 CTLA4。KD6001 显著阻断 CTLA-4 与 CD80 (IC₅₀：16 ng/mL) 和 CD86 的相互作用。KD6001 可增强 PHA 激活的人类淋巴细胞中 IL-2 和 IFNγ 的表达，并表现出强大的抗肿瘤作用。KD6001 可有效抑制 MC38、B16 和 Hepa1-6 肿瘤小鼠模型中的肿瘤生长。KD6001 可用于癌症研究，例如晚期黑色素瘤、肝细胞癌和肝癌。

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KD6001 Chemical Structure

CAS No. : 2983061-18-1

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KD6001 相关抗体

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生物活性

纯度 & 产品资料

参考文献

生物活性

KD6001 is a humanized IgG1κ monoclonal antibody, targeting CTLA4. KD6001 significantly disrupts CTLA-4 interactions with CD80 (IC₅₀: 16 ng/mL) and CD86. KD6001 enhances IL-2 and IFNγ expression in PHA-activated human lymphocytes and exhibits potent antitumor effects. KD6001 effectively inhibits tumor growth in MC38, B16, and Hepa1-6 tumor mice model. KD6001 can be used for cancers research, such as advanced melanoma, hepatocellular carcinoma and liver cancer^[1].

同型

Human IgG1 kappa

推荐同型对照抗体

Human IgG1 kappa, Isotype Control

IC₅₀ & Target
CTLA4

基因 ID

1493 [NCBI]

Accession

P16410

靶点

CTLA4

应用

ELISA, FACS, Functional assay

偶联物

Unconjugated

复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.

CAS 号
2983061-18-1

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

Data Sheet (518 KB) 抗体抑制剂使用指南 (1152 KB)

参考文献

[1]. Janss T, et al. EOS-215, a first-in-class TREM2 antagonist, designed to reprogram the tumor microenvironment and overcome resistance[J]. Cancer Research, 2025, 85(8_Supplement_1): 3136-3136.

[1]. Janss T, et al. EOS-215, a first-in-class TREM2 antagonist, designed to reprogram the tumor microenvironment and overcome resistance[J]. Cancer Research, 2025, 85(8_Supplement_1): 3136-3136.

KD6001 相关分类

抗体抑制剂

Biosimilar 抗体

单克隆抗体

Cancer

肿瘤靶向治疗肿瘤免疫

Immunology/Inflammation

CTLA-4

摩尔计算器

稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量浓度体积分子量 *

= × ×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start) × 体积 _(start) = 浓度 _(final) × 体积 _(final)

× = ×

C1 V1 C2 V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

KD60012983061-18-1KD 6001KD-6001CTLA-4Cytotoxic T-lymphocyte-associated protein 4CD152Monoclonal antibodyAntitumorMC38/B16/Hepa1-6 tumor mice modelAdvanced melanomaHepatocellular carcinomaLiver cancerInhibitorinhibitorinhibit

您最近查看的产品:

生物活性	KD6001 is a humanized IgG1κ monoclonal antibody, targeting CTLA4. KD6001 significantly disrupts CTLA-4 interactions with CD80 (IC₅₀: 16 ng/mL) and CD86. KD6001 enhances IL-2 and IFNγ expression in PHA-activated human lymphocytes and exhibits potent antitumor effects. KD6001 effectively inhibits tumor growth in MC38, B16, and Hepa1-6 tumor mice model. KD6001 can be used for cancers research, such as advanced melanoma, hepatocellular carcinoma and liver cancer^[1].
同型	Human IgG1 kappa
推荐同型对照抗体	Human IgG1 kappa, Isotype Control
IC₅₀ & Target	CTLA4
基因 ID	1493 [NCBI]
Accession	P16410
靶点	CTLA4
应用	ELISA, FACS, Functional assay
偶联物	Unconjugated
复溶方法	The product can be reconstituted/diluted with sterile PBS or saline.
CAS 号	2983061-18-1
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料	Data Sheet (518 KB) 抗体抑制剂使用指南 (1152 KB)
参考文献	[1]. Janss T, et al. EOS-215, a first-in-class TREM2 antagonist, designed to reprogram the tumor microenvironment and overcome resistance[J]. Cancer Research, 2025, 85(8_Supplement_1): 3136-3136.

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

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沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

KD6001

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生物活性

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参考文献

KD6001 相关分类

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稀释计算器

The molarity calculator equation

The dilution calculator equation

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KD6001

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KD6001 相关抗体

KD6001 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

纯度 & 产品资料

参考文献

KD6001 相关分类

摩尔计算器

稀释计算器

The molarity calculator equation

The dilution calculator equation

Keywords:

您最近查看的产品:

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