1. Anti-infection
  2. HSV
  3. Lactoferrin

Lactoferrin (乳铁蛋白) 是中性粒细胞释放的物质。Lactoferrin 是一种具有口服活性的多功能铁结合糖蛋白。Lactoferrin 可防止细胞粘附、细胞集落的生长和扩散。Lactoferrin 还具有抗病毒活性,抑制微生物和病毒粘附和进入宿主细胞。此外,Lactoferrin 具有抗炎、免疫调节和抗癌活性。

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Lactoferrin Chemical Structure

Lactoferrin Chemical Structure

CAS No. : 936541-36-5

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10 mg ¥500
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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lactoferrin is a substance released by neutrophils. Lactoferrin is an orally active multifunctional iron binding glycoprotein. Lactoferrin prevents cell adhesion, growth and spreading of cell colonies. Lactoferrin also has antiviral activity and inhibits microbial and viral adhesion and entry into host cells. Besides, Lactoferrin has anti-inflammatory, immunomodulatory, and anti-cancer activities[1][2][3].

体外研究
(In Vitro)

Lactoferrin (0-1 000 μg/mL,7 天) 以剂量依赖性方式抑制上皮细胞 (HaCaT) 生长[1]
Lactoferrin (500 μg/mL,12 天) 抑制 HaCaT 细胞集落的扩散和生长[1]
Lactoferrin (人或牛乳铁蛋白,1.41 μM 和 0.12 μM)可抑制 Vero 细胞中的 HSV-1 感染达 50%[4]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Lactoferrin (重组人乳铁蛋白) (1,000 mg/kg,口服灌胃,每天两次,持续 8 天) 可抑制 80% 的 T 细胞免疫功能低下的 nu/nu 小鼠鳞状细胞癌 (O12) 肿瘤的生长[5]
Lactoferrin (牛乳铁蛋白) (100 和 200 mg/kg,口服灌胃,连续 30 天) 对败血症诱发的急性肺损伤大鼠模型显示出保护作用
[6]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Squamous cell carcinoma model (O12 cell injected into the left flank of nu/numice)[5]
Dosage: 1,000 mg/kg
Administration: oral gavage, twice daily for 8 days
Result: Inhibited the tumor growth by 80%.
Animal Model: Sepsis-induced acute lung injury rat model[6]
Dosage: 100 and 200 mg/kg
Administration: oral gavage,for 30 consecutive days
Result: Reduced the wet/dry ratio of lung tissue by 30.7% and 61.3%, and lipid peroxidation by 22.3% and 67%, at concentrations of 100 and 200mg/kg.
Reduced Inflammatory markers, neutrophils, lymphocytes and total cell count.
Reduced MPO activity.
Clinical Trial
CAS 号
性状

固体

颜色

Off-white to pink

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O 中的溶解度 : ≥ 50 mg/mL

* "≥" means soluble, but saturation unknown.

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Lactoferrin 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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