2. Others GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reference Standards Adrenergic Receptor Calcium Channel Potassium Channel Reactive Oxygen Species (ROS)
  4. Landiolol hydrochloride (Standard)

Landiolol hydrochloride (Standard)  (Synonyms: 盐酸兰地洛尔(Standard); ONO1101 hydrochloride (Standard))

目录号: HY-100607AR 纯度: ≥98%
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Landiolol (ONO1101) hydrochloride (Standard) 是 Landiolol hydrochloride (HY-100607A) 的分析标准品。本产品用于研究及分析应用。Landiolol (ONO1101) hydrochloride 是一种高选择性的超短效 β1 肾上腺素受体竞争性抑制剂。Landiolol hydrochloride 特异性阻断心脏 β1 受体，降低心率和心肌耗氧量。Landiolol hydrochloride 在脓毒症模型中抑制 TNF-α 诱导的线粒体过度氧消耗和活性氧 (ROS) 生成，减轻肾损伤。Landiolol hydrochloride 对心脏离子通道 (如 L 型钙电流、内向整流钾电流) 影响甚微，负性肌力作用较弱。Landiolol hydrochloride 可用于围手术期心动过速控制、脓毒症相关急性肾损伤的保护研究。

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Landiolol hydrochloride (Standard) Chemical Structure

Landiolol hydrochloride (Standard) Chemical Structure

CAS No. : 144481-98-1

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生物活性

Landiolol (ONO1101) hydrochloride (Standard) is the analytical standard of Landiolol hydrochloride (HY-100607A). This product is intended for research and analytical applications. Landiolol (ONO1101) hydrochloride is a highly selective, ultra-short-acting competitive inhibitor of β1 adrenergic receptors. Landiolol hydrochloride specifically blocks cardiac β1 receptors, reducing heart rate and myocardial oxygen consumption. Landiolol hydrochloride inhibits TNF-α-induced excessive mitochondrial oxygen consumption and reactive oxygen species production in a sepsis model, alleviating renal injury. Landiolol hydrochloride has little effect on cardiac ion channels (such as L-type calcium current and inward rectifier potassium current) and has a weak negative inotropic effect. Landiolol hydrochloride can be used for perioperative tachycardia control and protection studies of sepsis-related acute kidney injury.

分子量

546.05

Formula

C25H40ClN3O8
CAS 号
中文名称

盐酸兰地洛尔(Standard)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Landiolol hydrochloride (Standard) 相关分类

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Landiolol hydrochloride (Standard)144481-98-1ONO1101 hydrochloride (Standard)盐酸兰地洛尔(Standard)Reference StandardsAdrenergic ReceptorCalcium ChannelPotassium ChannelReactive Oxygen Species (ROS)Beta ReceptorCa2+ channelsCa channelsKcsAInhibitorinhibitorinhibit

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