2. NF-κB
  3. NF-κB
  4. Laurotetanine

Laurotetanine  (Synonyms: (+)-Laurotetanine)

目录号: HY-117616
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Laurotetanine ((+)-Laurotetanine) 是一种口服有效的异喹啉类生物碱，可从 Litsea cubeba (Lour.) Pers 的根中提取。Laurotetanine 通过下调 MUC5AC 和 NF-κB 信号通路抑制 IgE、组胺和炎症反应发挥抗哮喘作用。

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Laurotetanine Chemical Structure

Laurotetanine Chemical Structure

CAS No. : 128-76-7

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Laurotetanine 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating MUC5AC and NF-κB signaling pathways[1].

体内研究
(In Vivo)

Laurotetanine ((+)-Laurotetanine; 20-60 mg/kg; p.o.; 每天，持续 21 天; SD 大鼠) 通过下调 MUC5AC 和 NF-κB 信号通路发挥抗哮喘作用。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley (SD) rats (180-220g) [1]
Dosage: 20, 40, and 60 mg/kg
Administration: Oral administration; daily, for 21 days
Result: Reduced inflammatory cells, including eosinophils, neutrophils, lymphocytes, and macrophages.
Decreased inflammatory cytokines viz IL-4, IL-6, IL-13 and increased IFN-γ.
Reduced serum IgE and histamine.
Decreased MUC5AC expression and increased NF-κB and IκB expression in lung tissues.
分子量

327.37

Formula

C19H21NO4
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Laurotetanine 相关分类

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Keywords:

Laurotetanine128-76-7(+)-LaurotetanineNF-κBNuclear factor-κBNuclear factor-kappaBisoquinoline alkaloidasthmaticMUC5ACIgEhistamineinflammatory reactionsInhibitorinhibitorinhibit

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